ALFAOMEGA Master Observational Trial

Launched by IFOM ETS - THE AIRC INSTITUTE OF MOLECULAR ONCOLOGY · Oct 7, 2019

Keywords

ClinConnect Summary

The ALFAOMEGA Master Observational Trial is a study focused on understanding colorectal cancer (CRC) better. Researchers are looking at how cancer cells and the body’s healthy cells interact over time. The goal is to find ways to improve treatment outcomes for patients with CRC, such as lowering the chances of the cancer coming back and increasing survival rates. This study will also help identify patients who could benefit from new experimental treatments.

To participate in this trial, you need to be at least 18 years old and have either been diagnosed with colorectal cancer or have strong signs of it based on medical tests. You’ll also need to provide some tissue samples from previous treatments. If you have other cancers or certain infections, you may not be eligible. If you join the study, you will contribute to important research that could help improve future treatments for colorectal cancer, and you might have the opportunity to learn more about your condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. TIER1 written Informed consent.
• • 2. Patients ≥18 years of age.
• • 3. Previous diagnosis of colorectal cancer, or a strong suspicion of CRC based on clinical and radiological findings.
• • 4. In patients with previous diagnosis of CRC availability of diagnostic Formalin-Fixed, Paraffin Embedded (FFPE) blocks (surgical resection and/or tumor biopsies), or at least 10 slides (preferably 20). FFPE tissue blocks are always preferred to slides.
• • 5. ECOG Performance status \< 2.
• Exclusion Criteria:
• • 1. Any other current malignancy or malignancy diagnosed or relapsed within the past 5 years (other than non-melanomatous skin cancer, stage 0 melanoma in situ, and in situ cervical cancer)
• • 2. Patient unable to comply with the study protocol owing to psychological, social or geographical reasons.
• • 3. Known Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) or syphilis infection.