Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Launched by WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY · Oct 10, 2019
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
The clinical trial titled "Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women" is studying how using one or multiple arterial grafts during heart surgery affects women’s health outcomes. Specifically, the researchers want to find out if using multiple arterial grafts (MAG) leads to better results, such as fewer serious heart problems or strokes, compared to using just one graft (SAG). They will include around 2,000 women who need coronary artery bypass surgery, which is a procedure to improve blood flow to the heart. Eligible participants are women aged 18 and older who are having their first heart surgery for significant blockages in their coronary arteries.
If you participate in this trial, you will be randomly assigned to receive either MAG or SAG during your surgery. The study will also look at how these different types of grafting affect your quality of life and overall well-being after the surgery. This means that the researchers will ask about your physical and mental health, as well as any symptoms you may experience. The trial is currently recruiting participants and aims to provide valuable insights that could improve heart surgery outcomes for women in the future.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • 1. Women patients ≥18 years old.
- • 2. Isolated coronary artery bypass grafting.
- • 3. Primary (first time) cardiac surgery procedure.
- • 4. Significant disease of the left main coronary artery or of the left anterior descending and the circumflex coronary system with or without disease of the right coronary artery.
- Exclusion Criteria:
- • Male gender
- • Single graft
- • Emergency operation
- • Myocardial infarction within 72 hours of surgery
- • Left ventricular ejection fraction \< 35%
- • Any concomitant cardiac or non-cardiac procedure
- • Previous cardiac surgery
- • Preoperative severe end-organ dysfunction (dialysis, liver failure, respiratory failure), cancer or any co-morbidity that reduces life expectancy to less than 5 years.
- • Inability to use the saphenous vein or to use both radial and right internal thoracic arteries
- • Anticipated need for coronary thrombo-endarterectomy
- • Planned hybrid revascularization
About Weill Medical College Of Cornell University
Weill Medical College of Cornell University is a leading academic institution dedicated to advancing medical research and education. As a prominent sponsor of clinical trials, it focuses on innovative healthcare solutions and the development of new therapies across various medical disciplines. The institution is committed to fostering collaborative research efforts that enhance patient care and improve health outcomes. With a robust infrastructure and a team of experienced researchers and clinicians, Weill Cornell aims to translate scientific discoveries into practical applications, ensuring a strong emphasis on ethical standards and regulatory compliance throughout the clinical trial process.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Ann Arbor, Michigan, United States
Houston, Texas, United States
Columbus, Ohio, United States
Philadelphia, Pennsylvania, United States
Baltimore, Maryland, United States
New York, New York, United States
Chicago, Illinois, United States
Winston Salem, North Carolina, United States
Cleveland, Ohio, United States
Toronto, Ontario, Canada
Iowa City, Iowa, United States
Providence, Rhode Island, United States
Copenhagen, , Denmark
Newark, New Jersey, United States
Sudbury, Ontario, Canada
Los Angeles, California, United States
Winnipeg, Manitoba, Canada
Pomona, California, United States
Pittsburgh, Pennsylvania, United States
Atlanta, Georgia, United States
Salt Lake City, Utah, United States
Durham, North Carolina, United States
Barcelona, , Spain
Omaha, Nebraska, United States
Wynnewood, Pennsylvania, United States
Greenville, North Carolina, United States
Saint Louis, Missouri, United States
Aurora, Colorado, United States
Ottawa, Ontario, Canada
Ridgewood, New Jersey, United States
Hamilton, Ontario, Canada
Zanesville, Ohio, United States
Zagreb, , Croatia
Hartford, Connecticut, United States
Gothenburg, , Sweden
Lincoln, Nebraska, United States
Vienna, , Austria
London, Ontario, Canada
Aalborg, , Denmark
New York, New York, United States
San Francisco, California, United States
London, , United Kingdom
Trier, , Germany
London, , United Kingdom
Edinburgh, , United Kingdom
Erlangen, , Germany
Innsbruck, , Austria
Queens, New York, United States
Montréal, Quebec, Canada
New York, New York, United States
Blackpool, Lancashire, United Kingdom
Toronto, Ontario, Canada
Springfield, Massachusetts, United States
Leiden, Zuid Holland, Netherlands
Middlesbrough, , United Kingdom
Graz, , Austria
Haifa, , Israel
Jena, , Germany
Bari, , Italy
Leicester, , United Kingdom
Roma, , Italy
Florence, , Italy
New Haven, Connecticut, United States
Seoul, , Korea, Republic Of
Brooklyn, New York, United States
Brescia, , Italy
Dallas, Texas, United States
Stoke On Trent, Staffordshire, United Kingdom
San Antonio, Texas, United States
Englewood, New Jersey, United States
Linz, , Austria
Shanghai, Shanghai, China
Sheffield, , United Kingdom
Wolverhampton, , United Kingdom
New York, New York, United States
Singapore, , Singapore
Rotterdam, , Netherlands
Montréal, Quebec, Canada
Katowice, , Poland
Roma, , Italy
Melbourne, , Australia
London, , United Kingdom
Worcester, Massachusetts, United States
Manchester, , United Kingdom
Vienna, , Austria
Porto Alegre, , Brazil
São Paulo, , Brazil
Vila Mariana, , Brazil
Saint John, New Brunswick, Canada
Montréal, Quebec, Canada
Ste Foy, Quebec, Canada
Beijing, Beijing, China
Changchun, Jilin, China
Tianjin, Tianjin, China
Hradec Králové, , Czechia
Nové Město, , Czechia
Bad Krozingen, Baden Wuerttemberg, Germany
Bad Oeynhausen, , Germany
Duisburg, , Germany
Duisburg, , Germany
Düsseldorf, , Germany
Frankfurt, , Germany
Gießen, , Germany
Göttingen, , Germany
Leipzig, , Germany
Stuttgart, , Germany
Coimbatore, Tamil Nadu, India
Hyderabad, Telangana, India
Cotignola, , Italy
Torino, , Italy
Bunkyō Ku, Tokyo, Japan
Saitama, , Japan
Seúl, , Korea, Republic Of
Maastricht, , Netherlands
Zabrze, , Poland
Coimbra, , Portugal
Lisboa, , Portugal
Porto, , Portugal
Belgrade, , Serbia
Elx, Alicante, Spain
Zhongzheng, Taipei, Taiwan
Berlin, , Germany
Montréal, , Canada
New Westminster, , Canada
Skopje, , North Macedonia
Tomsk, , Russian Federation
Madrid, , Spain
Pamplona, , Spain
Hull, , United Kingdom
Royal Oak, Michigan, United States
Omaha, Nebraska, United States
St. John's, Newfoundland And Labrador, Canada
Essen, , Germany
Bergamo, , Italy
Multiple Locations, Oxford, United Kingdom
Clydebank, , United Kingdom
Liverpool, , United Kingdom
Galveston, Texas, United States
Clayton, , Australia
Gdańsk, , Poland
Porto, , Portugal
Stockholm, , Sweden
Cambridge, , United Kingdom
Patients applied
Trial Officials
Mario Gaudino, Prof/PhD/MD
Principal Investigator
Weill Medical College of Cornell University
Stephen Fremes, MD
Principal Investigator
Sunnybrook Health Sciences Centre
Ruth Masterson Creber, RN, PhD
Principal Investigator
Columbia University
C. Noel Bairey Merz, MD
Principal Investigator
Cedars-Sinai
Karla Ballman, PhD
Principal Investigator
Weill Medical College of Cornell University
Sean O'Brien, PhD
Principal Investigator
Duke University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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