Comparative Imaging Assessment of Valvular Heart Disease

Launched by THE CLEVELAND CLINIC · Oct 11, 2019

Keywords

ClinConnect Summary

This clinical trial is investigating different imaging methods to understand heart valve diseases better. Specifically, it will compare several techniques used to measure how well the heart is functioning, especially in patients with conditions like aortic stenosis (narrowing of the heart's aortic valve) and aortic regurgitation (where the aortic valve doesn't close properly). The goal is to see how these methods stack up against each other and how accurately they can assess the heart's performance using advanced imaging called cardiac magnetic resonance (CMR).

To participate in this trial, individuals must be between 18 and 90 years old and have suspected moderate to severe heart valve issues based on previous medical evaluations. Participants should also have a specific type of heart device (CRT) implanted and have reduced heart function. However, people with certain heart conditions, like severe valve dysfunction or significant anxiety related to enclosed spaces (claustrophobia), may not qualify. Those who join can expect to undergo various imaging tests to help researchers learn more about heart valve diseases and improve future treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18-90 years of age
• • Suspected moderate or severe MR,AR or AS on the basis of prior known clinical history or clinical exam.
• • Suspected CRT "non-responder" with an implanted MRI compatible CRT device and reduced ejection fraction
• Exclusion Criteria:
• • Acute traumatic cardiac injury
• • Aortic dissection or aortic root rupture
• • Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD
• • Presence of A-V fistula or intracardiac shunts
• • Any contraindications to CMR
• • Moderate or severe dysfunction in multiple valves
• • Patients with significant claustrophobia