VItamin C in Thermal injuRY: The VICToRY Trial

Launched by CLINICAL EVALUATION RESEARCH UNIT AT KINGSTON GENERAL HOSPITAL · Oct 22, 2019

Keywords

ClinConnect Summary

The VICToRY Trial is a clinical study looking at the effects of high doses of intravenous vitamin C on critically ill patients with serious burn injuries. The goal is to see if giving vitamin C, along with standard medical care, can help these patients recover faster, have better organ function, and improve their chances of survival compared to those who do not receive vitamin C. In this trial, half of the participants will receive the vitamin, while the other half will receive a placebo, which is a harmless substance that looks like the treatment but has no active ingredients.

To be eligible for the trial, participants must be at least 18 years old and have deep burns that cover at least 20% of their body, requiring skin grafting. However, certain individuals, such as those who are pregnant, have specific health conditions, or are already receiving vitamin C treatments, will not be able to participate. If you or someone you know is interested in this study, it’s important to discuss this with a healthcare provider to see if it’s a good fit. Participants can expect to receive standard care for their burns, along with either the vitamin C treatment or the placebo, and their health will be closely monitored throughout the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years of age or older
• • Deep 2nd and/or 3rd degree burns requiring skin grafting
• • Minimum burn size of ≥ 20% Total Body Surface Area (TBSA)
• Exclusion Criteria:
• • \>24 hours from admission to participating hospital to consent.
• • Patients admitted to burn unit \>24 from injury or accident.
• • Patients who are moribund (not expected to survive the next 72 hours).
• • Pregnancy (pregnancy will be ruled out as part of standard of care) or lactating.
• • Enrollment in another industry sponsored ICU intervention study.
• • Receiving high-dose IV vitamin C already (enteral or oral vitamin C is allowed).
• • Known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• • Recent history of kidney stones (within the last year).
• • Concomitant use of hydroxycobalamin (vitamin B12) for suspected cyanide poisoning.