Proportional Assisted Ventilation and Pressure Support Ventilation in Adult Patients With Prolonged Ventilation
Launched by KAOHSIUNG VETERANS GENERAL HOSPITAL. · Oct 24, 2019
Trial Information
Current as of May 24, 2025
Completed
Keywords
ClinConnect Summary
Pressure support ventilation (PSV) the most frequently used mode of ventilator support in intensive care units, but has several demerits. Proportional assist ventilation with load-adjustable gain factors (PAV+) is a promising mode with better patient synchrony and weaning advantages. However, weaning outcome of PAV+ in patients with prolonged mechanical ventilation has not been evaluated before. We conducted a prospective randomized controlled trial in a tertiary medical center. This study aimed to compare the effectiveness between PAV+ and PSV for weaning adult patients with prolonged mech...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients with prolonged mechanical ventilation and transfer to respiratory care center, age of 20 years or older, at least 1 time of extubation failure or spontaneous breathing trial failure in ICU, stable hemodynamics, no vasopressor use, FiO2 = 0.40 or less, external positive end-expiratory pressure = 5 cmH2O or less, PaO2 \> 60 mmHg, and body temperature \< 38ºC (within 24 hours).
- Exclusion Criteria:
- • Patients with bronchopleural fistulas, central neurological disorders, hemodialysis, and those with pressure support level already \< 15 cmH2O.
About Kaohsiung Veterans General Hospital.
Kaohsiung Veterans General Hospital is a leading medical institution in Taiwan, renowned for its commitment to advancing healthcare through innovative clinical research and patient-centered care. As a prominent sponsor of clinical trials, the hospital combines cutting-edge medical technology with a team of experienced researchers and healthcare professionals dedicated to improving treatment outcomes and enhancing the quality of life for veterans and the broader community. With a focus on a wide range of therapeutic areas, Kaohsiung Veterans General Hospital actively contributes to the global medical research landscape, fostering collaboration and knowledge exchange to drive significant advancements in clinical practice.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Kaohsiung City, , Taiwan
Patients applied
Trial Officials
Chiu-Fan Chen, MD
Principal Investigator
Kaohsiung Veterans General Hospital.
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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