Impact of Preoxygenation Time on End-tidal Oxygen Concentration and on Hypoxic Events Occurring After Intubation in the Intensive Care Unit.

Launched by CENTRE HOSPITALIER RÉGIONAL D'ORLÉANS · Oct 31, 2019

Keywords

ClinConnect Summary

This is a multicenter randomized controlled pilot study. 110 patients who require intubation in the ICU will be randomly assigned, with a 1:1 ratio, to 3 or 5 minutes of preoxygenation duration. EtO2 will be continuously measured but hidden to the clinician. The primary outcome measure will be the obtention of an optimal preoxygenation defined by an EtO2 \>90%. Secondary outcomes include the occurrence of hypoxia and complications during the procedure.

A pulse oximetry (SpO2) greater than or equal to 96% (SpO2 ≥ 96%) at the end of preoxygenation will be the target in each group. If at the ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients older than 18 years
• • Requiring intubation in ICU
• • Free express oral and informed consent of the patient or a proxy in case of impossibility for the patient to consent; emergency inclusion possible when legal representatives and patient's family are not present
• Exclusion Criteria:
• • Intubation for cardiac arrest
• • End-tidal oxygen concentration monitoring not available
• • Preoxygenation with high-flow nasal oxygenation
• • Previous participation to the study
• • Patient known, at time of inclusion, as being under guardianship, tutorship or curator
• • Pregnancy or breastfeeding
• • Lack of social security number