Duke APOL1 Research Biorepository

Launched by DUKE UNIVERSITY · Nov 8, 2019

Keywords

ClinConnect Summary

The Duke APOL1 Research Biorepository is a clinical trial focused on understanding end-stage kidney disease, particularly in individuals of African descent. The study aims to collect important samples from participants to investigate a specific gene mutation known as ApoL1, which is linked to kidney problems and is mainly found in black individuals. By studying both those with kidney disease and healthy black adults aged 50 and older, researchers hope to learn more about how this gene affects kidney health.

To be eligible for the trial, participants should be self-identified African Americans, Afro-Caribbean, or other black individuals, either with end-stage kidney disease or without any signs of kidney issues. Healthy adults in the same demographic without a history of kidney disease can also participate as control subjects. If you join the study, you will help contribute to vital research that may improve understanding and treatment of kidney disease in your community.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Majority of subjects recruited for this study will be self-identified African Americans, Afro-Caribbean and other black individuals. Study subjects will include individuals at various stages of kidney disease and those without any clinical evidence of kidney disease.
• • Healthy black adults, age 50 and older with no known history of kidney disease will be recruited as controls
• Exclusion Criteria:
• • Black adult cases with diabetic nephropathy
• • Healthy controls with kidney disease