Norfloxacin With Itopride Versus Norfloxacin in Secondary Prophylaxis of Spontaneous Bacterial Peritonitis

Launched by TANTA UNIVERSITY · Nov 10, 2019

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of combining two medications, Norfloxacin and Itopride, compared to using Norfloxacin alone for preventing a serious infection called Spontaneous Bacterial Peritonitis (SBP) in patients with liver disease (cirrhosis) and fluid buildup in the abdomen (ascites). The goal is to see if adding Itopride can help improve protection against this infection in patients who have already experienced it before.

To be part of this study, participants need to be adults with cirrhosis who have had at least one previous episode of SBP. Unfortunately, people with allergies to the medications being tested, recent antibiotic use, certain types of cancer, or those who are pregnant or breastfeeding cannot participate. Those who join the trial can expect regular check-ins with the research team to monitor their health and response to the medications. This trial is currently looking for volunteers, and all genders are welcome to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • cirrhotic patients with ascites who had previous episodes of SBP.
• Exclusion Criteria:
• • 1. Allergy or contraindication for the used drugs. 2. Recent antibiotics therapy in the previous 2 weeks. 3. Patients with hepatocellular carcinoma or other neoplasia. 4. Pregnant and lactating women.