Magnesium Infusion for Pain Management in Critically Ill Trauma Patients

Launched by UNIVERSITY OF CALIFORNIA, DAVIS · Nov 14, 2019

Keywords

ClinConnect Summary

This clinical trial is studying the use of magnesium sulfate, a medication that contains magnesium, to help manage pain in trauma patients who are in the Intensive Care Unit (ICU). Magnesium has been shown to reduce pain after surgery, and the researchers want to see if it can also help trauma patients by potentially decreasing the need for stronger pain medications like narcotics. In this study, some patients will receive magnesium through an IV (a needle in the vein), while others will receive a normal saline solution, which is just a mix of salt and water.

To participate in this study, patients must be adults aged 18 to 99 who have been admitted to the ICU due to trauma. They need to be able to give their consent and have a specific pain management plan in place. However, some patients may not be eligible, such as those with certain heart or kidney conditions, severe injuries, or those who have used strong pain medications recently. Participants can expect to receive either the study medication or the saline solution while their pain is monitored, helping researchers understand how effective magnesium is for pain relief in critically ill trauma patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All trauma patients admitted to an adult intensive care unit
• • Signed informed consent
• • Hospital or trauma multimodal pain management order set used for pain management
• • Ages 18-99
• Exclusion Criteria:
• • Admission to the Pediatric Intensive Care Unit.
• • Head Abbreviated Injury Score (AIS) of greater than 1
• • Known heart failure with reduced ejection fraction (EF \< 40%)
• • Renal failure (GFR \< 60)
• • Cardiac arrhythmia (except for sinus tachycardia)
• • Greater than 5% TBSA burn injuries
• • Moderate to severe alcohol withdrawal protocol ordered for patient
• • Regular use of opioids in the week prior to injury
• • Receiving continuous infusion of opioids
• • Patients expected to require general anesthesia between 24 and 48 hours after admission (during study drug administration)
• • Patients unable to provide consent is unavailable
• • Patients unable to provide a pain score
• • Pregnancy
• • Prisoners