Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections

Launched by THE REPUBLICAN RESEARCH AND PRACTICAL CENTER FOR EPIDEMIOLOGY AND MICROBIOLOGY · Nov 24, 2019

Keywords

ClinConnect Summary

* To study the state of the immune system in patients with severe bacterial infections (on the model of pneumonia, infective endocarditis, sepsis): spontaneous and stimulated production of reactive oxygen species by blood neutrophils; spontaneous necroptosis, apoptosis and pyroptosis of neutrophils; the content of blood leukocyte subpopulations.
* Assess the clinical, biochemical status, state of the lipid transport system of patients with severe bacterial infections (in the model of pneumonia, infective endocarditis, sepsis), including determination of the cholesterol content in the cell m...

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Eligibility criteria

• Inclusion Criteria:
• • community-acquired pneumonia, severe course (according to IDSA / ATs criteria) and / or sepsis with different localization of the primary focus (SOFA\> 2);
• • the patient's ability to comply with the instructions of the research doctor and follow the procedures required by the test protocol;
• • informed consent.
• Exclusion Criteria:
• • acute and chronic heart failure;
• • renal failure;
• • acute and chronic liver failure;
• • taking medications of the statin group during the last month before the study;
• • diabetes in the stage of clinical and metabolic decompensation;
• • acute and chronic leukemia, severe anemia;
• • pregnancy or lactation;
• • HIV infection;
• • drug addiction;
• • immunosuppressive therapy;
• • malignant neoplasms over the past 5 years.