ABR Characteristics and Salivary Cortisone Concentration in Noise-exposed Workers

Launched by UNIVERSITY HOSPITAL SESTRE MILOSRDNICE · Nov 27, 2019

Keywords

ClinConnect Summary

The research is cross-sectional. The expected duration of the survey is at least 18 months. Assuming that the characteristics of the auditory evoked brainstem potentials are correlated with salivary cortisone concentration with a correlation coefficient of 0.4, a test power of 80% and a significance level of α = 0.05, at least 46 subjects should be included in the study. Test power analysis was performed using MedCalc Statistical Software, version 19.1 (MedCalc Software bv, Ostend, Belgium; https://www.medcalc.org; 2019). According to the data distribution (Kolmogorov-Smirnov test), appropr...

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Eligibility criteria

• Inclusion Criteria:
• • 1. male and female
• • 2. ages 19-35
• • 3. exposure to noise level ≥ 85 dB (A) per week at the workplace
• • 4. work in noise from 1 to 16 years
• • 5. workplace not involving exposure to carbon disulfide or a mixture of organic solvents that have toxic effects on the ear (toluene, xylene and styrene)
• • 6. unilaterally or bilaterally normal otoscopic findings
• • 7. unilaterally or bilaterally tympanogram: peak pressure value ± 50 daPa at 226 Hz with eardrum mobility of 0.3 to 1.3 mL
• Exclusion Criteria:
• • 1. information about an earlier sudden hearing loss
• • 2. information on chronic middle ear inflammation
• • 3. information on ear surgery (except placement of ventilation tubes in the eardrum)
• • 4. information on dizziness associated with hearing loss and noise
• • 5. information on insomnia
• • 6. current use of oral corticosteroids
• • 7. bilaterally found air-bone gap greater than 15 dB