The Treatment of Cartilaginous Lesions and Concomitant Anterior Cruciate Ligament Reconstruction

Launched by ISTITUTO ORTOPEDICO RIZZOLI · Nov 28, 2019

Keywords

ClinConnect Summary

This clinical trial is studying a specific surgical treatment for patients who have torn their anterior cruciate ligament (ACL) and also have damage to the cartilage in their knee. The goal is to compare the outcomes of two different surgical approaches: one that includes a technique called nanofractures and one that does not. Researchers want to see how effective these methods are in helping patients recover both clinically (how they feel and function) and through imaging (pictures of the knee).

To participate in this trial, individuals need to be between 18 and 55 years old and have a complete ACL injury along with significant cartilage damage that is confirmed during surgery. Participants should be generally healthy and able to provide consent. Throughout the trial, participants will receive regular follow-ups to monitor their progress. It's important to note that certain health conditions, such as severe diabetes or previous knee surgeries, may prevent someone from being eligible for the study. Overall, this trial aims to improve treatment options for people facing these common knee injuries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male or female patients, 18 \< age \< 55;
• • 2. Patients with complete ACL injury candidates for surgical reconstruction of the same;
• • 3. Cartilaginous lesion of the femur-tibial compartment of grade III-IV ICRS ≤3 cm2 confirmed intra-operatively;
• • 4. Patients without evidence of osteoarthritis
• • 5. Patients' ability and consent to participate in clinical and radiological follow-up;
• • 6. Signature of informed consent.
• Exclusion Criteria:
• • 1. Patients incapable of understanding and of wanting;
• • 2. State of immunodepression;
• • 3. Patients with malignant neoplasms;
• • 4. Patients suffering from rheumatic diseases;
• • 5. Patients suffering from non-compensated diabetes;
• • 6. Patients suffering from uncompensated thyroid metabolic disorders;
• • 7. Patients abusing alcoholic beverages, drugs or drugs;
• • 8. Patients with axial deviations\> 5 °;
• • 9. Body Mass Index\> 35;
• • 10. Patients treated with surgery at the same knee in the previous 12 months.
• • 11. Cartilaginous lesions grade I-II according to the ICRS score.
• • 12. Cartilage lesions with a diameter greater than 3 cm².
• • 13. Non-suturable meniscal lesions requiring meniscectomy\> 50% and patients with previous meniscectomies\> 50% in the same compartment.
• • 14. Need for further associated surgical procedures in addition to the reconstruction of ACL and possibly the nanofractures.