COLO-COHORT (Colorectal Cancer Cohort) Study

Launched by SOUTH TYNESIDE AND SUNDERLAND NHS FOUNDATION TRUST · Dec 2, 2019

Keywords

ClinConnect Summary

The COLO-COHORT study is a research project designed to help identify which patients are at high risk for colorectal cancer and related conditions, like colorectal adenomas (which are growths in the colon that could lead to cancer). By understanding these risk factors, researchers hope to develop a model that can predict who might be more likely to develop these conditions. This study is currently looking for participants, including anyone aged 30 and older who is going for a colonoscopy, whether for routine screening or due to certain symptoms.

Eligible participants will be those able to understand and give consent, and who are attending colonoscopies for various reasons, such as family history of colorectal issues or specific symptoms like weight loss or rectal bleeding. Participants will undergo standard procedures during their colonoscopy, and their information will help researchers build a more accurate risk prediction tool. It's important to note that individuals with certain medical conditions, like known polyposis syndrome or those who have had total colectomy, won't be able to participate. By joining the study, participants can contribute to important research that may improve future screening and prevention strategies for colorectal cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Group A
• • Aged ≥30 years\* and able to give informed consent
• • Patients attending colonoscopy
• • Through Bowel Cancer Screening Programme (FIT positive, Bowelscope conversion, surveillance)
• • Through standard NHS care (most commonly due to iron deficiency anaemia, altered bowel habit, weight loss, rectal bleeding, planned polypectomy\*\*, those referred on basis of family history, abnormal cross-sectional imaging, polyp surveillance or post CRC surveillance)
• • The age of 30 was chosen to ensure that this is a population likely to be enriched for colorectal neoplasia with neoplasia below this age uncommon \*\*In those attending for planned polypectomy, the results from the initial colonoscopy and the endoscopy where the polypectomy is undertaken will be summated for purposes of calculating the neoplasia profile
• • (COLO-SPEED) Group B
• • Any patient attending for colonoscopy and able to give informed consent
• • ≥ 18 years old
• • Patient from the North of England
• Exclusion Criteria:
• • Group A
• • Unable to give informed consent
• • Known polyposis syndrome
• • Previous total colectomy
• • Known colonic stricture which would limit complete colonoscopy
• • Attending for planned therapeutic procedure other than polypectomy, such as insertion of colonic stent
• • Attending for assessment of known inflammatory bowel disease (IBD) activity or for IBD surveillance
• • Patients currently recruited into an interventional CTIMP for CRC prevention\*
• • COLO-SPEED (Group B) \*\*
• • Unable to give informed consent
• • Not in a centre supported by COLO-SPEED infrastructure (North of England)