Effect of Acupuncture on Mild to Moderate Active Crohn's Disease

Launched by SHANGHAI INSTITUTE OF ACUPUNCTURE, MOXIBUSTION AND MERIDIAN · Dec 4, 2019

Keywords

ClinConnect Summary

This clinical trial is looking at how acupuncture may help people with mild to moderate Crohn's disease, which is a type of inflammatory bowel disease that can cause various digestive issues. Researchers want to see if acupuncture can improve symptoms and also how it affects brain activity and certain metabolic processes in the body. They are currently recruiting participants aged 16 to 70 who have not found relief with traditional medications like mesalazine or steroids, and who have never had acupuncture before.

If you or someone you know is interested in participating, it's important to know that participants should not be pregnant or have serious health issues that could interfere with the study. Those who qualify will receive acupuncture treatments and, through the study, may help researchers learn more about how acupuncture can impact Crohn's disease. Participants will also contribute to understanding how acupuncture affects the brain and overall health in this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. aged 16-70;
• • 2. patients with mild or moderate active disease (150 ≤ CDAI \< 450);
• • 3. patients who are not responsive, intolerant, dependent or refused to use at least mesalazine, glucocorticoid, immunomodulator (azathioprine, methotrexate), anti TNF alpha preparation;
• • 4. patients were not taking medication or were only taking one or more of the following drugs: \[prednisone ≤15mg/d, azathioprine (≤1mg/kg/d), methotrexate (≤15mg/w) or mesalazine (≤4g/d)\] and prednisone was used for at least 1 month, while azathioprine, methotrexate or mesalazine was used for at least 3 months;
• • 5. those who did not use anti-TNF alpha and other agents within 3 months before entering the study;
• • 6. those who have never experienced acupuncture;
• • 7. patients signing informed consent.
• Exclusion Criteria:
• • 1. patients who are recently pregnant or in pregnancy or lactation;
• • 2. patients with serious organic diseases;
• • 3. patients diagnosed as psychosis;
• • 4. patients who take antibiotics, probiotics, traditional Chinese medicine and other drugs at the same time, or who suffer from multiple diseases and need to take other drugs for a long time, and may affect the observation of the efficacy of this trial;
• • 5. severe skin diseases (such as erythema nodosum, pyoderma gangrenosum, etc.), eye diseases (such as iritis, uveitis, etc.), thromboembolic diseases and other serious extraintestinal manifestations;
• • 6. there are serious intestinal fistula, abdominal abscess, intestinal stenosis and obstruction, perianal abscess, gastrointestinal hemorrhage, intestinal perforation and other complications;
• • 7. patients with short bowel syndrome who have undergone abdominal or gastrointestinal surgery in the past half a year;
• • 8. there are skin diseases or defects in the selected area of acupuncture and moxibustion that cannot be performed.