The GAstric Precancerous Conditions Study

Launched by STANFORD UNIVERSITY · Dec 5, 2019

Keywords

ClinConnect Summary

The GAstric Precancerous Conditions Study (GAPS) is a research trial focused on understanding gastric intestinal metaplasia (GIM), a condition that can increase the risk of developing gastric cancer. Each year, about 27,000 Americans are diagnosed with gastric cancer, often at a late stage when treatment options are limited. This study aims to improve the early detection of GIM and find biological markers that can help predict which cases might progress to cancer. Researchers will recruit participants who are scheduled for endoscopy (a procedure to examine the stomach) and will collect samples from their saliva and blood, as well as perform detailed examinations of their stomach tissue.

To be eligible for the study, participants must be between the ages of 35 and 84 and have specific reasons for undergoing an endoscopy, such as abdominal pain or a family history of gastric cancer. Participants can expect to undergo regular check-ups every two years, which will include additional biopsies and tests to track any changes in their condition. This study is essential for developing better ways to identify and monitor individuals at risk for gastric cancer, ultimately leading to improved outcomes.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria: Subjects between the ages of 35 and 84, who are undergoing outpatient endoscopy for the following indications are eligible: abdominal pain, dyspepsia, iron deficiency anemia, Helicobacter assessment, surveillance of suspected or known intestinal metaplasia, evaluation for family history of gastric cancer
• Exclusion Criteria:
• • Cannot give consent
• • Have history of gastric surgery
• • Have history of solid tumor or bone marrow transplant
• • Platelet Count \< 70 or international normalized ratio \> 1.5