ARrest RESpiraTory Failure From PNEUMONIA

Launched by STANFORD UNIVERSITY · Dec 9, 2019

Keywords

ClinConnect Summary

The ARrest RESpiraTory Failure From PNEUMONIA clinical trial is studying whether a combination of two inhaled medications—an inhaled corticosteroid and a beta agonist—can help prevent serious breathing problems in hospitalized patients with pneumonia and low oxygen levels (hypoxemia). This study aims to find out if these medications are effective compared to a placebo, which is a harmless substance that looks like the medication but has no active ingredients.

To participate in this trial, patients need to be at least 18 years old and have severe pneumonia that requires hospitalization, along with low oxygen levels. Patients will be monitored closely, and those who meet the criteria may be randomly assigned to receive either the medications or a placebo. It's important to note that not everyone will qualify; for instance, those who need immediate intubation or have certain medical conditions will be excluded. Overall, the trial hopes to improve treatment options for patients suffering from pneumonia and related breathing difficulties.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients 18 years or older with
• Severe pneumonia defined as:
• 1. Hospitalization for acute (defined as ≤ 14 days) onset of symptoms (cough, sputum production, or dyspnea), AND 2. Radiographic evidence of pneumonia by chest radiograph or CT scan, AND 3. One of the following:
• • 1. Evidence of systemic inflammation (temperature \< 35◦C or \> 38◦C OR WBC \> or \< upper or lower limits for site OR procalcitonin \> 0.5 mcg/L), OR
• • 2. Known current immunosuppression preventing inflammatory response, OR
• • 3. High clinical suspicion of pneumonia with microbiologic confirmation of infection. Microbiologic confirmation will include a positive nasal swab for a known respiratory virus; a sputum culture growing a likely pathogenic organism plus moderate or greater WBCs (not required for immunocompromised patients); or a positive blood culture with a likely pathogenic organism - e.g., ¼ vials with S. Epidermidis would NOT qualify)
• • AND Hypoxemia defined as new requirement for daytime supplemental oxygen with SpO2 \< 92% on room air, ≤ 96% on ≥ 2 L/min oxygen, or \> 6L/min or non-invasive ventilation regardless of SpO2 at enrollment. Patients admitted with pneumonia but not meeting criteria for hypoxemia will be followed for up to 48 hours from ED admission to enrolling hospital to assess for development of qualifying hypoxemia.
• Exclusion Criteria:
• • Inability to randomize within 48 hours of presentation to enrolling hospital (randomization beyond 24 hours will be limited to patients with persistent hypoxemia defined by an SpO2 \< 97% while on \> 3L/min O2)
• • Intubation (or impending intubation) prior to enrollment
• • a. Patients receiving HFNC oxygen or NIV prior to enrollment are not excluded
• • A condition requiring inhaled corticosteroids or beta-agonists (patients receiving inhaled beta-agonists in the ED without an established indication will be eligible if treating clinician is willing to discontinue subsequent treatments)
• • Chronic systemic steroid therapy equivalent to \>10 mg prednisone
• • COVID-19 positive patients receiving \> 6 mg dexamethasone (40 mg prednisone equivalent dose) except for stress dose steroids for septic shock
• • Non-COVID-19 pneumonia patients receiving systemic steroid \> 10 mg prednisone except for stress dose steroids for septic shock
• • Chronic lung or neuromuscular disease requiring daytime oxygen or mechanical ventilation other than for obstructive sleep apnea (OSA) or obesity hypoventilation syndrome
• • Not anticipated to survive \> 48 hours or not expected to require \> 48 hours of hospitalization
• • Contraindication or allergy to inhaled corticosteroids or beta-agonists
• • Patients with heart rate \> 130 bpm, ventricular tachycardia or new supraventricular tachycardia within last 4 hours will be potentially eligible for enrollment after the condition has resolved
• • Patients with K+ \< 3.0 will be potentially eligible for enrollment after the condition has resolved
• • Patient not committed to full support other than intubation or resuscitation (i.e., DNR/DNI status allowed)
• • Pregnancy
• • Incarcerated individual
• • Physician refusal of consent to protocol
• • Patient/surrogate refusal of consent to protocol