Complex Adult Deformity Surgery (CADS)

Launched by INTERNATIONAL SPINE STUDY GROUP FOUNDATION · Dec 10, 2019

Keywords

ClinConnect Summary

The Complex Adult Deformity Surgery (CADS) trial is studying the outcomes of surgical treatments for adults with spinal deformities, such as scoliosis and kyphosis. The goal is to find the best practices for surgery, including how well patients recover and any complications that may arise after surgery. Researchers want to understand what factors might affect the success of the surgery and how to improve patient care to minimize risks and enhance recovery.

To be eligible for this trial, participants should be adults aged 65 and older who have specific types of spinal deformities, including congenital, degenerative, or idiopathic conditions. They must also have a detailed body scan (called EOS radiography) to assess their spine. However, individuals with certain conditions like active tumors, infections, or serious neurological diseases cannot participate. If you join the trial, you can expect thorough evaluations and close monitoring throughout the surgical process and recovery to help improve future treatments for others with similar conditions.

Gender

ALL

Eligibility criteria

• Criteria:
• Inclusion Criteria:
• • 1. Diagnosis of adult congenital, degenerative, idiopathic or iatrogenic spinal deformity
• • 2. Full body EOS radiographic assessment (sagittal and coronal visualization from skull to foot)
• 3. Complex patients are defined as and meeting any one of the subsequent criteria:
• 1. Radiographic criteria:
• • PI-LL ≥ 25 degrees
• • TPA ≥ 30 degrees
• • SVA\>15cm
• • Thoracic scoliosis ≥ 70 degrees
• • Thoracolumbar/lumbar scoliosis ≥ 50 degrees
• • Global coronal malalignment \>7cm
• 2. Procedural criteria:
• • Posterior spinal fusion \> 12 levels
• • 3 column osteotomy or ACR
• 3. Geriatric criteria:
• • Age \>65 years and minimum 7 levels of spinal instrumentation during surgery
• Exclusion Criteria:
• • 1. Age \<18 years of age
• • 2. Active spine tumor or infection
• • 3. Deformity due to acute trauma
• • 4. Neuromuscular conditions/diseases (Parkinson's, Multiple Sclerosis, Post-polio syndrome)
• • 5. Syndromic scoliosis
• • 6. Inflammatory arthritis/auto immune diseases (Rheumatoid arthritis, Lupus, Ankylosing Spondylitis)
• • 7. Prisoners
• • 8. Women who are pregnant
• • 9. Non English speaking patients