Optimising Pacing for Contractility 2

Launched by UNIVERSITY OF LEEDS · Dec 13, 2019

Keywords

ClinConnect Summary

The clinical trial titled "Optimising Pacing for Contractility 2" is studying how different programming settings on a pacemaker can improve exercise ability and quality of life for patients with chronic heart failure (CHF). Researchers have found that keeping the heart rate in a specific range can help patients exercise longer and feel better. This trial aims to compare three different programming methods: one that uses the optimal heart rate, one that uses standard settings, and one that doesn’t adjust the heart rate at all, over a period of six months.

To take part in this study, patients need to have chronic heart failure and a cardiac pacemaker, be able to walk on a treadmill, and be willing to give consent for the trial. Over 450 participants will undergo tests to find the best heart rate for their condition, complete a treadmill exercise test, and fill out quality of life questionnaires. Afterward, they will be randomly assigned to one of the three programming groups and will return for follow-up tests after six months. This study is important as it may lead to better management of heart failure, helping patients exercise more and improve their overall well-being.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Clinical, echocardiographic and neurohormonal evidence of heart failure
• • Cardiac pacemaker,
• • Able to perform a peak exercise test,
• • Willing and able to give informed consent.
• Exclusion Criteria:
• • Angina pectoris symptoms limiting exercise tolerance,
• • Unstable heart failure symptoms (medical therapy changes in last three months), Poor image quality,
• • Calcium channel blockers (CCBs).