Effect of Giving Reduced Fluid in Children After Trauma

Launched by COLUMBIA UNIVERSITY · Dec 14, 2019

Keywords

ClinConnect Summary

This clinical trial is looking at how much intravenous (IV) fluid should be given to children who have experienced trauma, such as injuries from accidents. Traditionally, doctors have given a lot of IV fluids to trauma patients, but recent studies in adults suggest that giving less fluid might actually help them recover better. This study aims to find out if the same is true for children, with the goal of creating clear guidelines for treating young trauma patients.

To be eligible for this trial, children must be between 6 months and 15 years old and have been admitted to the pediatric intensive care unit (PICU) directly from the emergency department or after surgery. Unfortunately, some children will not be able to participate, including those with certain heart or kidney conditions, traumatic brain injuries, or those who are expected to leave the PICU quickly. If a child joins the study, they can expect to receive careful monitoring and specific treatment related to their fluid needs, helping us learn more about the best care for young patients after trauma.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Trauma patients older than 6 months and younger than 15 years admitted to the pediatric intensive care unit (PICU)
• • Patients admitted to the PICU directly from the Emergency Department (ED)
• • Patients admitted to the PICU from the operating room (OR)
• • Patients transferred to PICU from outside facility ED (need to have been in ED 12 hours or less)
• Exclusion Criteria:
• • Patients transferred to PICU from outside PICU or inpatient floor
• • Patients transferred to PICU from outside facility ED if \>12 hours
• • Patients expected to be discharged from the PICU within 24 hours
• • Patient with congenital heart disease as defined by a congenital cardiac defect requiring surgery or medication
• • Patient with diagnosis of chronic cardiac condition (e.g. hypertension, cardiac arrhythmia)
• • Patients with chronic kidney disease as defined by an abnormality of kidney structure or function, present for more than 3 months, with implications to health
• • Post-operative transplant, cardiac, and neurosurgical patients
• • Patients with traumatic brain injury
• • Patients with any disease that may affect baseline blood pressure and heart rate (endocrine disorders, certain genetic disorders, mitochondrial diseases)
• • Hypotension requiring vasopressor therapy
• • If massive transfusion protocol initiated