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SEarchiNg BiomarkErs Cerebral Amyloid Angiopathy (SENECA)

Launched by FONDAZIONE I.R.C.C.S. ISTITUTO NEUROLOGICO CARLO BESTA · Dec 17, 2019

Trial Information

Current as of July 26, 2025

Recruiting

Keywords

ClinConnect Summary

The SENECA trial is a research study focusing on a condition called Cerebral Amyloid Angiopathy (CAA), which affects blood vessels in the brain and can lead to serious issues like bleeding in the brain and memory problems, especially in older adults. This study aims to better understand how CAA progresses and to find markers that can help doctors diagnose and manage the disease more effectively. By gathering information from a large group of patients and studying their brain scans, researchers hope to improve our understanding of how CAA works and how to treat it.

To participate in the study, you need to be at least 55 years old and have a diagnosis of CAA, which means you’ve had specific brain scans that show signs of the condition. The study is open to all genders, but it’s important to note that people with other conditions causing brain bleeding or those who cannot have an MRI scan cannot take part. If you join, you can expect to contribute to valuable research that may help improve future treatments and care for people with CAA.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • All consecutive patients ≥55 years (with the exception of genetic cases), referred to the participating centres, with a diagnosis of possible probable and definite symptomatic or asymptomatic CAA, defined according to the modified Boston neuroradiological criteria, who had undergone at least one brain MRI (mandatory requirement for inclusion of the patient in the study) will be recruited.
  • Exclusion Criteria:
  • evidence of other causes of cerebral hemorrhage (brain tumors, arteriovenous malformations, aneurysms, cavernous angiomas), contraindications to brain MRI, pregnancy and breastfeeding

About Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta is a prestigious research institute in Italy dedicated to advancing the field of neurology through innovative clinical trials and translational research. As a leading center of excellence, it focuses on the diagnosis and treatment of neurological disorders, fostering collaboration among clinicians, researchers, and healthcare professionals. The foundation is committed to improving patient outcomes by integrating cutting-edge scientific research with clinical practice, ensuring that groundbreaking therapies and interventions are effectively translated into real-world applications for individuals affected by neurological conditions.

Locations

Milano, , Italy

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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