Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis

Launched by KOS CARE SRL - ISTITUTO DI RIABILITAZIONE SANTO STEFANO · Dec 18, 2019

Keywords

ClinConnect Summary

INTRODUCTION Gonarthrosis is the most common disorder of the musculoskeletal system, with an age-related prevalence varying between 12-55%. The treatment of OA is mostly symptomatic and includes the use of analgesics, NSAIDs, exercise and even surgery. However, the use of long-term NSAIDs is associated with potentially serious side effects, with a high risk of hospitalization and death. As a result, the use of alternative and complementary therapies (CAM), such as nutritional therapies in patients with OA, is extremely frequent.

The objective of this study will be to evaluate the effective...

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Eligibility criteria

• Inclusion Criteria:
• * Presence of osteoarthritis of the knee. Traditional American College of Rheumatology criteria, which are based on the presence of pain (gonalgia) plus at least three of the following characteristics, will be used for the diagnosis of osteoarthritis of the knee:
• • Age \> 50 years
• • Stiffness in the morning \< 30 minutes
• • Presence of articular rusting
• • Painfulness of the bones
• • Tumefaction of the bones
• • Absence of palpable heat
• Exclusion Criteria:
• • - pregnancy and breastfeeding (if the potential participant does not declare to be in a menopausal state)
• • other specific contraindications/intolerances to the compounds contained in the supplement (e.g. celiac disease, allergy)
• • simultaneous intake of other supplements
• • to be at the time of enrolment for treatment with anti-inflammatory or pain-relieving treatment for other clinical conditions
• • Participation in other clinical studies
• • State of inability to understand or desire