Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Counterregulation

Launched by PENNINGTON BIOMEDICAL RESEARCH CENTER · Dec 17, 2019

Keywords

ClinConnect Summary

This clinical trial is studying a new way to predict hypoglycemia, which is a condition where blood sugar levels drop too low and can be dangerous for people with diabetes. Researchers have identified a potential biomarker, called glial acetate metabolism, that might help determine who is more likely to experience hypoglycemic episodes after taking insulin. The study will involve advanced imaging techniques to measure this biomarker and will compare it with a controlled procedure that safely lowers blood sugar levels to see how the body responds.

To participate in this study, individuals must be healthy men or women between the ages of 18 and 40, with a body mass index (BMI) between 20 and 30. They should not have any history of diabetes or other medical conditions that could interfere with the study. Participants can expect to undergo some imaging tests and a controlled blood sugar test over a few days. This research could lead to better ways to manage diabetes and prevent dangerous low blood sugar episodes in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy male or female
• • Ages 18-40 years
• • BMI between 20 kg/m2 and 30 kg/m2 (±0.5 kg/m2 will be accepted)
• • Medically cleared for participation in the study
• Exclusion Criteria:
• • Contraindication to MRI
• • Consume \>10 alcoholic drinks/week
• • History of chronic smoking or have quit less than 10 years ago
• • History of clinically diagnosed diabetes or a fasting blood glucose \>126 mg/dL
• • Average screening blood pressure \>140/90 mmHg
• • History of cardiovascular disease
• • Pregnant, planning to become pregnant, or breastfeeding
• • Use of medications affecting glucose metabolism, e.g., benzodiazepines, thiazide diuretics, cortisone, and prednisone.
• • Use of beta-adrenergic antagonists.
• • Based on the investigative team's clinical judgement, a subject may not be appropriate for participation in the study.