Early Versus Late Initiation of ECMO (Extracorporal Membrane Oxygenation) Trial (ELIEO-Trial)

Launched by UNIVERSITY HOSPITAL TUEBINGEN · Dec 19, 2019

Keywords

ClinConnect Summary

The Early Versus Late Initiation of ECMO (ELIEO-Trial) is a research study designed to find out whether starting a treatment called Extracorporeal Membrane Oxygenation (ECMO) right away or waiting until conservative treatments fail is better for patients with Acute Respiratory Distress Syndrome (ARDS). ARDS is a serious lung condition that makes it hard to breathe. In this trial, patients who develop ARDS will be assigned to either receive ECMO immediately upon entering the intensive care unit or to receive standard treatments first, with the option of starting ECMO later if needed. The goal is to see which approach helps patients recover better.

To be eligible for this trial, participants must be adults aged 18 and older who have been diagnosed with ARDS within the past 7 days and are enrolled within 96 hours of their symptoms beginning. They should also be willing to receive full intensive care support. If someone participates, they can expect to be monitored closely until they leave the hospital. It’s important to note that this trial is not yet recruiting participants, so it’s still in the planning stages.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ARDS as defined according to the Berlin Definition1
• • The term "acute onset" is defined as follow: the duration of the hypoxemia criterion and the chest radiograph criterion must be ≤ 7 days at the time of randomization.
• • Patients must be enrolled within 96 hours of onset of ARDS and no later than 7 days from the initiation of mechanical ventilation.
• Exclusion Criteria:
• • Age less than 18 years
• • More than 7 days since initiation of mechanical ventilation
• • more than 96 hours since meeting inclusion criteria
• • patient, surrogate or physician not committed to full intensive care support
• • pregnancy