Comparison of Pre- vs Post-dilution Haemodiafiltration in Children
Launched by GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST · Dec 20, 2019
Trial Information
Current as of June 23, 2025
Active, not recruiting
Keywords
ClinConnect Summary
This clinical trial is studying two types of haemodiafiltration (HDF) in children who need dialysis. Haemodiafiltration is a method used to clean the blood of patients with kidney problems, and this trial aims to compare pre-dilution and post-dilution HDF. Research suggests that post-dilution HDF might help children have better heart health, lower blood pressure, and improved growth. However, pre-dilution HDF may remove more toxins from the blood. The goal of this study is to find out which method works best for children on dialysis.
To be eligible for this trial, children aged 5 to 20 years who have been on maintenance dialysis for at least three months can participate, but they must have been receiving post-dilution HDF for at least four weeks before starting the study. Participants should have stable access to their blood vessels for dialysis and meet specific health criteria. During the study, children will continue their usual dialysis treatments while helping researchers gather important information about the best way to perform dialysis in young patients. This trial is currently active but not recruiting new participants.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Patients treated in paediatric dialysis centres between 5-20 years of age
- • 2. Receiving maintenance haemodialysis with HD or HDF for the preceding 3 months
- • 3. In post-dilution HDF for at least 4 weeks before the start of the study
- • 4. Patients with stable vascular access (central line or arteriovenous fistula) and no plan to change access modality for the duration of the study
- • 5. Provision for ultrapure water for HDF (defined as containing \<0.1 colony forming unit /ml and \<0.03 endotoxin unit/ml) documented in the month prior to study start
- Exclusion Criteria:
- • 1. Incident dialysis patients (on HD or HDF for \< 3 months)
- • 2. Patients with acute infections in the preceding 2 weeks
- • 3. Patients with underlying chronic inflammatory disorders (Including vasculitis)
- • 4. Single pool Kt/V less than 1.2 in the month prior to the study start.
- • 5. Children who have haemoglobin concentrations lower than 10 g/dL
About Great Ormond Street Hospital For Children Nhs Foundation Trust
Great Ormond Street Hospital for Children NHS Foundation Trust is a leading pediatric healthcare institution in the UK, renowned for its commitment to advancing child health through innovative research and clinical trials. As a prominent sponsor of clinical studies, the Trust focuses on developing and evaluating new treatments and therapies for a wide range of pediatric conditions, leveraging its extensive expertise and state-of-the-art facilities. With a multidisciplinary team of specialists and a patient-centered approach, Great Ormond Street Hospital aims to improve outcomes for children and contribute to the global body of medical knowledge.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
London, , United Kingdom
Lyon, Bron, France
Heidelberg, , Germany
Istanbul, , Turkey
Patients applied
Trial Officials
Rukshana Shroff, MD PhD
Study Chair
Great Ormond Street Children's Hospital, London, UK
Salim Caliskan, Prof Dr
Principal Investigator
Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
Nur Canpolat, Assoc Prof
Principal Investigator
Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
Ayse Agbas, MD
Principal Investigator
University of Health Sciences, Haseki Education and Research Hospital, Istanbul, Turkey
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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