Prospective Study on Primary Aldosteronism in Resistant Hypertension

Launched by UNIVERSITY OF TURIN, ITALY · Dec 26, 2019

Keywords

ClinConnect Summary

This clinical trial is studying a condition called primary aldosteronism (PA) in people who have resistant hypertension, which means their blood pressure remains high even when they are taking at least three different medications to lower it. Researchers want to understand how common PA is in these patients and how it might contribute to heart problems, regardless of their blood pressure levels.

To participate in this study, individuals need to be between 18 and 80 years old and have a diagnosis of resistant hypertension. However, some people will not be eligible, such as those with certain other health conditions or those who do not take their medications as prescribed. Participants will have the opportunity to contribute to important research that could lead to better understanding and treatment of resistant hypertension. The study is currently recruiting, and anyone interested should talk to their doctor for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age over 18 and under 80 years old;
• • diagnosis of resistant hypertension defined as: uncontrolled blood pressure at ambulatory blood pressure measurement (ABPM), despite the use of at least 3 antihypertensive drugs at full dose, including a diuretic.
• Exclusion Criteria:
• • age under 18 or over 80 years old;
• • pseudo-resistant hypertension (poor medication adherence, high salt intake);
• • previous cardiovascular disease;
• • insulin treated diabetes mellitus;
• • other than primary aldosteronism cause of secondary hypertension (obstructive sleep apnea, renal artery stenosis, pheochromocytoma/paraganglioma, primary hyperparathyroidism, autonomous cortisol secretion or over hypercortisolism);
• • liver cirrhosis;
• • chronic heart failure;
• • known malignant neoplasm;
• • chronic disease with major organ involvement;
• • excessive alcohol ingestion;
• • current steroids assumption;
• • use of sympathomimetic drugs;
• • use of contraceptives.