Biomarkers of Increased Free Living Sleep Time

Launched by UNIVERSITY OF UTAH · Dec 26, 2019

Keywords

ClinConnect Summary

This clinical trial is looking at ways to help people who usually get less than 6 hours of sleep per night to increase their sleep duration to the recommended 7 hours. The researchers want to understand how getting more sleep affects certain substances in the blood, specifically focusing on branched-chain amino acids and insulin sensitivity. They hope to find out if these substances can help identify whether someone is getting enough sleep or not.

To be eligible for this study, participants should be between 18 and 35 years old, have a body mass index (BMI) between 18.5 and 24.9, and typically sleep less than 6 hours each night. They should also have lived at a high altitude (like Denver) for at least 3 months and not be very active in terms of exercise. Participants will be asked to change their sleeping habits and may undergo blood tests to track changes. It’s important to note that individuals with certain medical conditions or those taking specific medications may not be able to join the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. 18-35 years old; men and women
• • a. Equal numbers of women and men will be included.
• • 2. Body Mass Index (BMI) of \> 18.5 and \<24.9.
• • 3. Inactive to habitual moderate physical activity level (\<5 days of exercise per week).
• • 4. Sleep/wake history: habitual sleep duration less than 6 hours per night.
• • 5. Altitude history: Potential participants must have lived at Denver altitude or higher for at least 3 months.
• Exclusion Criteria:
• • 1. Any clinically significant unstable medical or surgical condition within the last year (treated or untreated).
• • 2. Any clinically significant psychiatric condition, as defined by DSM-IV-TR. I
• • 3. Any clinically significant sleep disorder.
• • 4. Use of prescription medications/supplements within one month or need of these medications at any time during the study.
• • 5. Symptoms of active illness (e.g., fever).
• • 6. Uncorrected visual impairment
• • 7. History of shift work in prior year or travel more than one time zone in three weeks prior to study.
• • 8. Participants must be entirely drug-free of illicit drugs, medications, nicotine and herbal products for one month prior to study.
• • 9. Blood donation in the 30 days prior to inpatient study.
• • 10. Ovulating women will be selected on the basis of a history of regular menstrual cycle ranging in length from 25-32 days with a maximum of three days variation month-to-month. They will have no history of prior gynecological pathology, be at least 1 year post-partum, not breast-feeding and not pregnant (HCG pregnancy test at screening and upon admission to the inpatient protocol).