Adenoid Cystic Carcinoma and Carbon Ion Only Irradiation

Launched by HEIDELBERG UNIVERSITY · Dec 27, 2019

Keywords

ClinConnect Summary

The ACCO study is a clinical trial that is exploring a new way to treat a rare type of cancer called adenoid cystic carcinoma, which affects the head and neck area. This trial specifically looks at using carbon ion radiation therapy alone, rather than the usual combination of carbon ions and photons (a type of light radiation). Researchers believe that using carbon ions alone could improve the control of the tumor over five years, increasing the success rate from 60% to 70%. The treatment is expected to take about four weeks, and participants will be monitored for five years afterward to track their progress and any side effects.

To participate in this trial, individuals must be between 18 and 80 years old and have a confirmed diagnosis of adenoid cystic carcinoma that cannot be surgically removed or has certain risk factors. They should also be able to understand and give consent for the study. However, people with advanced cancer that has spread widely, previous radiation treatment in the head and neck area, or certain medical conditions may not be eligible. This study is currently recruiting participants, and it’s important for those interested to discuss their options with their healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Histologically confirmed adenoid cystic carcinoma in the head and neck area
• * Indication for irradiation:
• • non-operable or
• • R1/R2 resected or
• • perineural sheat invasion (Pn+) or
• • pT3/pT4
• • Informed consent
• • KI \> 60% or ECOG 0/1 (minimum: self-sufficiency, normal activity or work not possible)
• • Age 18-80 years
• Exclusion Criteria:
• • rejection of the study by the patient
• • Patient is not able to consent
• • Stage IV (distant metastases), except lung metastases \< 1cm
• • lymph node involvement (clinical or pathological)
• • Previous radiotherapy in the head and neck area
• • Active medical implants for which there is no ion radiation authorization at the time of treatment (e.g., cardiac pacemaker, defibrillator, ...)
• • Contraindication to MR imaging
• • Simultaneous participation in another clinical study that could influence the outcome of this study or the other study
• • Pregnancy