Neoadjuvant Irradiation of Retroperitoneal Soft Tissue Sarcoma With Ions Retro-Ion

Launched by UNIVERSITY HOSPITAL HEIDELBERG · Jan 3, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a new way to treat patients with a type of cancer called retroperitoneal soft tissue sarcoma. The researchers want to see if using a special kind of radiation therapy, called hypofractionated accelerated radiation, is safe and effective when given before surgery to remove the tumor. This treatment uses advanced technology, like protons or carbon ions, to target the cancer while minimizing damage to surrounding tissues. The goal is to understand how well this approach works and whether it causes any serious side effects.

To participate in the trial, patients need to be at least 18 years old and have a confirmed diagnosis of retroperitoneal soft tissue sarcoma that can be surgically removed. They should also be able to walk and take care of themselves fairly well. However, patients with advanced cancer that has spread to other parts of the body, certain types of tumors, or those with specific medical devices may not be eligible. If someone joins the trial, they can expect to receive radiation treatment followed by surgery. The research team will closely monitor their health throughout the process to ensure their safety.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Histologically confirmed retroperitoneal soft-tissue sarcoma which is resectable or marginally resectable
• • Karnofsky index of ≥ 70%
• • Age from 18 years
• • Completed patient information and written consent
• • ability to give consent
• Exclusion Criteria:
• • Stage IV (distant metastases)
• • Lymphogenic metastasis
• • Metal implants at the level of the sarcoma, which influence the treatment planning
• • Previous radiation therapy in the treatment area
• • Desmoid tumors, peritoneal sarcomatosis, GIST
• • Simultaneous participation in another clinical study that could influence the results of the respective study
• • Active medical implants for which there is no license for ion irradiation at the time of treatment (e.g. pacemaker, defibrillator)
• • Pregnant women