COMPuter-assisted Self-training to Improve EXecutive Function

Launched by BISPEBJERG HOSPITAL · Jan 13, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how a special computer-based therapy can help improve thinking skills, specifically focusing on executive functions, in patients who have had a stroke, cardiac arrest, or have Parkinson's disease. Executive functions are important cognitive skills that help us plan, organize, and manage our daily activities. The therapy being tested will be compared to regular computer activities that stimulate the brain.

To participate, individuals need to be at least 18 years old and have a diagnosis of stroke, cardiac arrest, or Parkinson's disease, with some level of working memory impairment. They should also have access to a computer and the internet at home. Participants will be asked to provide informed consent, meaning they agree to take part in the study after understanding what it involves. If you or a loved one meet these criteria, you may be eligible to join this trial, which could offer new ways to improve cognitive functioning after these conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • A diagnose of stroke, cardiac arrest or Parkinson's disease.
• • Aged 18 years or older.
• • Impaired working memory measured with CABPad working memory test, cut off for inclusion: 5 symbols or less backwards
• • Computer and internet access at home.
• • Providing informed consent.
• • Inclusion criteria specific for stroke
• • Inclusion within 6 months post-stroke
• • Stroke confirmed by clinical findings and imaging, both AIS and ICH is allowed.
• • Initial stroke severity \>/= NIHSS 3.
• • Inclusion criteria specific for cardiac arrest
• • • Inclusion within 6 months post ictus.
• • Inclusion criteria specific for Parkinson's disease
• • Clinical diagnosis of PD.
• • Anti-parkinsonian medical treatment (dopaminergic or other).
• Exclusion Criteria:
• • Informed consent not provided
• • Other neurological or psychiatric disease which is expected to influence the patient's ability to participate in the trial according to the investigator
• • Not able to participate according to investigator
• • Exclusion criteria specific for stroke
• • Patients with massive anosognosia for executive dysfunction or patients with no subjective feeling of executive dysfunction (Patient sustains total denial of executive symptoms over time)
• • Patients with severe aphasia, in which it is unclear whether the patient's performance on a neuropsychological test-battery is due to aphasia and not executive dysfunction.
• • Exclusion criteria specific for cardiac arrest • None
• • Exclusion criteria specific for PD
• • • Diagnosis of PD Dementia according to the MDS PD Dementia criteria