Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period

Launched by BRIGHAM AND WOMEN'S HOSPITAL · Jan 17, 2020

Keywords

ClinConnect Summary

This is randomized controlled trial to investigate if enalapril is superior to nifedipine in terms of medical resources used in postpartum women with hypertension. These are both antihypertensives we commonly use in the postpartum period for women with hypertension in pregnancy but we do not know which medication works better at decreasing prolonged hospitalizations, the number of unscheduled medical visits and/or readmissions to the hospital.

Nifedipine is more traditionally used and well-validated by current medical literature. However, enalapril's mechanism of action is better suited to...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • diagnosis of any hypertensive disorder of pregnancy/postpartum period or chronic hypertension
• • provider wanting to initiate antihypertensive in the postpartum period
• • the patient is not currently on \>1 antihypertensive
• • plans to receive postpartum care at the hospital or affiliated clinic
• Exclusion Criteria:
• • sustained pulse \<60 or \>120 BPM over four hours
• • allergy to any of the antihypertensives
• • creatinine greater than or equal to 1.5
• • strict contraindication to any of the antihypertensives
• • history of failed treatment with any of the antihypertensives