Angiogenic Markers in Cerebrovascular Disease (ANFIS)

Launched by CEDARS-SINAI MEDICAL CENTER · Jan 21, 2020

Keywords

ClinConnect Summary

Intracranial atherosclerosis (ICAS) is the most common cause of stroke worldwide. It accounts for at least 10% of all strokes in the United States and as much as 67% in countries with predominantly Asian, Hispanic, and Black populations. ICAS carries a worse prognosis than other stroke etiologies, with an annual rate of recurrent stroke and death of 15% despite intensive medical management, and as high as 35% in certain populations. Recent randomized controlled clinical trials have shown that angioplasty with stenting and bypass surgery fail to improve outcomes in patients with ICAS.

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Eligibility criteria

• Inclusion Criteria:
• • 70% to 99% ICAS of a major intracranial artery diagnosed by angio, TCD, MRA, or CTA.
• Exclusion Criteria:
• • Intracranial tumor or vascular malformation.
• • Any hemorrhagic infarct within 14 days before enrollment or any other intracranial hemorrhage (subarachnoid, subdural, or epidural) within 30 days.
• • Intracranial arterial stenosis related to arterial dissection or any known infectious or vasculitic disease.
• • Presence of any unequivocal cardiac sources of embolism.
• • Major surgery within previous 30 days before enrollment or planned in the next 180 days after enrollment,
• • Severe neurologic deficit that renders the patient incapable of living independently.