Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Jan 22, 2020

Keywords

ClinConnect Summary

This clinical trial is investigating new ways to measure how well the brain regulates its blood flow after a serious injury. Researchers are looking at two specific methods called Transfer Function Analysis and Wavelet Coherence to see how fluctuations in blood pressure relate to blood flow and oxygen levels in the brain. This study is important because understanding these relationships can help doctors take better care of children who have suffered traumatic brain injuries.

To be eligible for this trial, patients must be between 28 days and 18 years old and have recently been admitted to the Pediatric Intensive Care Unit (PICU) at Children's Medical Center Dallas due to an acute brain injury. This could be from various causes, like severe head trauma, cardiac arrest, or a stroke. Participants will have some monitoring devices placed on them as part of their usual medical care, and they may need to wear a special headpiece to help with the study. Overall, this trial aims to improve our understanding of brain injuries in children and how to effectively monitor and treat them.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ages 28 days-18 years admitted to the PICU at Children's Medical Center Dallas
• • Acute presentation (\< 24 hour) onset of neurologic injury
• * Acute neurologic injury can be due to any of the following mechanisms:
• • Severe accidental or abusive traumatic brain injury
• • Severe encephalopathy secondary to cardiac arrest
• • Spontaneous intracranial hemorrhage
• • Status epilepticus
• • Stroke
• • Presence of or pending placement of invasive indwelling arterial line for stand medical care
• • Any patient with an ICP monitor placed as standard of care
• Exclusion Criteria:
• • Patients without an arterial line placed as standard of care
• • Patients unable to cooperate with wearing a TCD headpiece device
• • Expected death within 24-48 hours
• • Inability to place NIRS probes or insonate TCD signal due to massive facial or cranial injury
• • Receiving an inhalational anesthetic agent
• • Hemoglobinopathy, myoglobinemia or and hyperbilirubinemia (due to inaccurate NIRS readings)