Impact of Estradiol on Endothelial Function in Peri-Menopausal Women

Launched by UNIVERSITY OF DELAWARE · Feb 1, 2020

Keywords

ClinConnect Summary

**Trial Summary: Impact of Estradiol on Endothelial Function in Peri-Menopausal Women**

This clinical trial is investigating how a hormone called estradiol (E2) affects blood vessel function in women going through perimenopause, which is the transition period before menopause. The study aims to understand how E2 influences the health of blood vessels, which can change as women get older. By learning more about these changes, researchers hope to find better ways to support women's health during this stage of life.

To participate in this study, women must be between 40 and 58 years old and experiencing changes in their menstrual cycles, such as longer cycles or missed periods. However, certain women cannot join, including those who are pregnant, have a history of serious health issues (like heart disease or cancer), or have recently used hormonal treatments. If you decide to participate, you will undergo tests to monitor your blood vessel function and may receive estradiol as part of the study. This research is important as it could lead to better understanding and treatments for women experiencing perimenopausal symptoms.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Peri-menopausal women between 40-58 years of age with variable cycles as defined by increase in cycle length of greater than 7 days within ten consecutive cycles, or amenorrhea for more than 2 months, but less than 12 months.
• Exclusion Criteria:
• • Women who are pregnant, planning on becoming pregnant, or are breast feeding;
• • Women who have a history of cardiovascular disease, blood clots (e.g, pulmonary embolism or deep vein thrombosis), stroke, cancer, or liver disease;
• • Women who have a body mass index less than 18 or greater than 35kg/m2;
• • Women who use tobacco products;
• • Women who's blood pressure is greater than 140/90 mmHg, have been diagnosed by a physician with hypertension or are taking medication for high blood pressure;
• • Women who have a neurological disease, or diabetes;
• • Women who have had a hysterectomy or have used hormones (birth control or hormone replacement) within the past 3 months;
• • Women who have a latex allergy.