Efficacy of Dienogest Versus Oral Contraceptive Pills on Pain Associated With Endometriosis

Launched by AMERICAN UNIVERSITY OF BEIRUT MEDICAL CENTER · Feb 3, 2020

Keywords

ClinConnect Summary

Endometriosis is defined as the presence of endometrial tissue outside the uterus, which induces a chronic inflammatory reaction. It is an estrogen-dependent associated with pelvic pain and infertility. It is a relatively common chronic gynecological disease that affects approximately 10% of reproductive aged women. Patients with endometriosis often suffer from dysmenorrhea, dyspareunia, dysuria, and chronic abdominal or pelvic pain, resulting in a severely limited quality of life. The aim of most medical therapies is to alleviate the severity of symptoms. Commonly used hormonal therapies i...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients confirmed or suspected of endometriosis on clinical evaluation (VAS score more than 5 and presence of subjective symptoms), surgical or imaging studies, and not taking any pain killer or other hormonal treatment for the moment
• • Age 20-45
• • Regular menstrual cycles
• • The presence of subjective symptoms during menstruation (at least one from among lower abdominal pain, lumbago, defecation pain, nausea, and headache)
• • The presence of subjective symptoms during non-menstruation (at least one from among lower abdominal pain, lumbago, defecation pain, dyspareunia, and pain on internal examination).
• Exclusion Criteria:
• • Undiagnosed genital bleeding
• • Use of any hormonal therapy for endometriosis within 16 weeks before enrollment
• • A history of severe adverse drug reactions or hypersensitivity to steroid hormone
• • Having undergone surgery therapy or surgical examination for endometriosis within a menstrual cycle before the start of medication
• • Previous failure of treatment with the OCP used in the current study
• • Contraindications to OCP or Dienogest use
• • Smokers \>35
• • A history or complication of thrombosis/embolism
• • Migraines with aura
• • Depression
• • Patients on anti-epileptics
• • Diabetes Mellitus with vascular involvement
• • Liver diseases
• • Known or suspected sex hormone dependent malignancies
• • Repeat surgery for endometriosis
• • Patient consulting for infertility
• • Pregnant or nursing
• • Planning for pregnancy in near future.