The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major
Launched by BENI-SUEF UNIVERSITY · Feb 6, 2020
Trial Information
Current as of May 06, 2025
Completed
Keywords
ClinConnect Summary
N-acetylcysteine( NAC) is a widely used mucolytic drug and several studies had reported its efficacy as anti oxidant. Patients with thalassemia major are at great risk for oxidative stress due to excess of b-globin chains and iron overload. In this study the investigators compared the effect of NAC on oxidative status , pretransfusion hemoglobin levels and iron overload in thalassemia patients before and after treatment with NAC for 3 months and with that of patients who served as controls.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Thalassemia major children on regular blood transfusion and iron chelation therapy
- Exclusion Criteria:
- • Renal or hepatic impairments
- • Complicated thalassemia major
- • Non adherence to therapy or follow up visits
- • Change in the iron chelation dose within 3 months before enrollment or during study period
About Beni Suef University
Beni-Suef University is a prominent academic institution in Egypt dedicated to advancing medical research and clinical trials aimed at improving healthcare outcomes. With a strong emphasis on innovation and collaboration, the university fosters a multidisciplinary approach to research, engaging faculty, students, and healthcare professionals in the pursuit of scientific knowledge. The institution is committed to adhering to the highest ethical standards and regulatory guidelines, ensuring that all clinical trials conducted under its auspices are designed to enhance patient care and contribute to the global body of medical research. Through its initiatives, Beni-Suef University aims to translate research findings into practical applications that benefit communities locally and internationally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Banī Suwayf, Beni Suef, Egypt
Patients applied
Trial Officials
Heba M Ahmed
Principal Investigator
Beni-Suef University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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