Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure

Launched by HARI NARAYAN · Feb 7, 2020

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how certain cancer treatments, specifically anthracycline chemotherapies like doxorubicin and daunorubicin, can affect the heart in young people. These treatments are effective against pediatric cancers but can lead to heart problems later on, such as heart failure. The researchers want to find better ways to identify which patients are at higher risk for heart issues before they develop significant heart problems. They will use specialized imaging tests to look for early signs of heart damage.

To participate in this study, individuals aged 13 to 39 who were diagnosed with cancer before the age of 22 and have received anthracycline treatment at least two years ago may be eligible. Participants should be able to speak either English or Spanish. However, those with certain heart conditions, medical issues that could affect the study, or metal implants that aren’t MRI-compatible will not be able to join. If selected, participants will undergo cardiac MRI, a type of scan that helps doctors see how well the heart is working. This trial aims to improve how we monitor and manage heart health in young cancer survivors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • English and Spanish speaking male and female subjects, ages 13-39 years old
• • Diagnosis of cancer at age \<22 years
• • Previously treated with anthracyline therapy for cancer, with diagnosis at least two years prior.
• Exclusion Criteria:
• • Patients who have a contraindication to cardiac MRI, including the presence of non-MRI compatible metallic implants.
• • Medical, psychiatric, and/or social disorder that would prevent successful completion of planned study testing or would preclude the subject from undergoing the cardiac MRI without anesthesia.
• • Patients with a history of congenital heart disease (more significant than a history of patent foramen ovale or patent ductus arteriosus).
• • Pregnancy (at the time of enrollment).