[18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging to Evaluate Biodistribution and Kinetics in Human Subjects

Launched by UNIVERSITY OF PENNSYLVANIA · Feb 10, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a special imaging drug called [18F]F-TMP, which is injected into the body to help doctors see areas where bacterial infections are active. The imaging test used in this study is called PET/CT, which combines two types of scans to give detailed pictures of what’s happening inside the body. The goal is to understand how this tracer moves and where it goes in patients with bacterial infections.

To be eligible for the trial, participants should be at least 18 years old and have a known or suspected bacterial infection, as determined by their doctor. They should also be able to understand the study and provide consent. However, individuals who have taken certain antibiotics recently, have serious health issues, or are pregnant or breastfeeding cannot participate. Those who join the trial can expect to receive the tracer injection and undergo imaging scans, helping researchers learn more about how this new imaging tool can help diagnose infections.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • At least 18 years of age
• • Known or suspected bacterial infection, per clinical documentation of suspected infection (e.g. lab results, pathology results, physician progress notes, clinical symptoms of infection)
• • Able to understand the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study-specific procedures
• Exclusion Criteria:
• • Antibiotic therapy with trimethoprim within 48h of the baseline PET/CT scan
• • Inability to tolerate imaging procedures, in the opinion of an investigator or treating physician
• • Unstable or other severe medical or psychological comorbidities that would compromise the subject's safety or successful participation in the study, in the opinion of an investigator or treating physician
• • Pregnant or breast feeding patients; a urine pregnancy test will be performed in women of child-bearing potential prior to \[18F\]F-TMP injection, to confirm non-pregnant status