Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Launched by NATIONAL CANCER INSTITUTE (NCI) · Feb 12, 2020
Trial Information
Current as of August 22, 2025
Recruiting
Keywords
ClinConnect Summary
The ALCHEMIST trial is a clinical study looking at whether adding a drug called pembrolizumab, which is a type of immunotherapy, to standard chemotherapy can improve treatment outcomes for patients with certain stages of non-small cell lung cancer (NSCLC) after their tumors have been surgically removed. The goal is to see if this combination helps the body's immune system better fight the cancer and potentially increase survival rates among patients with stage IIA, IIB, IIIA, or IIIB NSCLC.
To participate in the trial, patients must be at least 18 years old, have completely had their lung cancer surgically removed, and meet specific health criteria, like having no active infections or serious other illnesses. They also need to have certain test results showing their cancer type and characteristics. Participants can expect to receive regular treatments and monitoring throughout the study. It’s important to know that women who can become pregnant will need to take a pregnancy test before joining the trial, as the study drug can affect fetal development. Overall, this trial seeks to find better treatment options for lung cancer patients by exploring new ways to enhance the effectiveness of existing therapies.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- * A female of childbearing potential is a sexually mature female who:
- • Has not undergone a hysterectomy or bilateral oophorectomy; or
- • Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months)
- • Local testing of EGFR with no EGFR exon 19 deletion or EGFR L858 R mutation (applicable to non-squamous patients only)
- • Local testing of ALK with no ALK rearrangement (failed testing is considered negative) (applicable to non-squamous patients only)
- • Local testing of PD-L1 immunohistochemistry (IHC) using one of the following assays: DAKO 22C3, DAKO 28-8, EIL3N or SP263
- • Completely resected stage IIA, IIB IIIA or IIIB (T3-4N2) non-small cell lung cancer (NSCLC) (squamous or non-squamous) with negative margins (complete R0 resection). Patients will be staged according to the 8th edition of the American Joint Committee on Cancer (AJCC) Staging Manual, 2017
- • Note: Patients with pathologic N2 disease, completely resected, are eligible. However, patients known to have N2 disease prior to surgery are not eligible; guidelines do not recommend up-front surgery for this population
- • Complete recovery from surgery. Registration to A081801 must be 30-77 days following surgery
- • No prior neoadjuvant or adjuvant therapy for current lung cancer diagnosis
- • No prior allogeneic tissue/solid organ transplant
- • Patients must NOT have uncontrolled intercurrent illness including, but not limited to, serious ongoing or active infection, symptomatic congestive heart failure, uncontrolled cardiac arrhythmia, unstable angina pectoris, that would limit compliance with study requirements
- • No current pneumonitis or history of (non-infectious) pneumonitis that required steroids
- • Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
- • Age \>= 18 years
- • Eastern Cooperative Oncology Group (ECOG) performance status (PS): 0-1
- • No active auto-immune disease that has required systemic treatment within the last 2 years (e.g., disease-modifying agents, corticosteroids, or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid release therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment
- • Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects
- • Therefore, for women of childbearing potential only, a negative pregnancy test done =\< 7 days prior to registration is required
- • No patients with a "currently active" second malignancy that is progressing or has required active treatment within the last 3 years. Participants with non-melanoma skin cancers, low grade or low-risk cancers, or stage I malignancies not requiring systemic therapy (e.g., prostate cancer requiring only observation or superficial bladder cancer), or carcinoma in situ (e.g., breast carcinoma or cervical cancer in situ) that have undergone potentially curative therapy are eligible
- • No hypersensitivity (\>= grade 3) to pembrolizumab and/or any of its excipients
- • No live vaccine within 30 days prior to registration. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., FluMist) are live attenuated vaccines and are not allowed
- • No known hepatitis C virus (defined as HCV ribonucleic acid \[RNA\] \[qualitative\] is detected) infection or known history of hepatitis B (defined as hepatitis B surface antigen \[HBsAg\] reactive)
- • Absolute neutrophil count (ANC) \>= 1,500/mm\^3
- • Platelet count \>= 100,000/mm\^3
- • Hemoglobin \>= 8 gm/dl
- • Calculated (Calc.) creatinine clearance \>= 45 mL/min
- • Total bilirubin =\< 1.5 x upper limit of normal (ULN)
- • Aspartate aminotransferase (AST) / alanine aminotransferase (ALT) =\< 2.5 x upper limit of normal (ULN)
About National Cancer Institute (Nci)
The National Cancer Institute (NCI) is a prominent component of the National Institutes of Health (NIH), dedicated to advancing cancer research and improving patient outcomes through innovative clinical trials. As a leading sponsor of cancer-related studies, NCI focuses on facilitating the development of new therapies, enhancing prevention strategies, and understanding the biology of cancer. The institute collaborates with academic institutions, healthcare providers, and industry partners to conduct rigorous clinical trials that aim to translate scientific discoveries into effective treatments. NCI’s commitment to fostering a robust research environment supports the mission to eliminate cancer as a major health problem.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Chicago, Illinois, United States
New Haven, Connecticut, United States
Brooklyn, New York, United States
Durham, North Carolina, United States
Milwaukee, Wisconsin, United States
Charleston, South Carolina, United States
Cleveland, Ohio, United States
Buffalo, New York, United States
Saint Louis, Missouri, United States
Philadelphia, Pennsylvania, United States
Flint, Michigan, United States
Providence, Rhode Island, United States
Boston, Massachusetts, United States
Denver, Colorado, United States
Denver, Colorado, United States
Lone Tree, Colorado, United States
Flint, Michigan, United States
Kalamazoo, Michigan, United States
Burnsville, Minnesota, United States
Edina, Minnesota, United States
Waconia, Minnesota, United States
Maywood, Illinois, United States
Loma Linda, California, United States
Peoria, Illinois, United States
South Bend, Indiana, United States
Baton Rouge, Louisiana, United States
Detroit, Michigan, United States
Boston, Massachusetts, United States
San Francisco, California, United States
Bangor, Maine, United States
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Green Bay, Wisconsin, United States
La Crosse, Wisconsin, United States
Great Falls, Montana, United States
Cleveland, Ohio, United States
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Ridgewood, New Jersey, United States
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Saint Paul, Minnesota, United States
Lewistown, Pennsylvania, United States
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Chanute, Kansas, United States
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Rochester, New York, United States
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Salina, Kansas, United States
Houma, Louisiana, United States
Chillicothe, Ohio, United States
Bryn Mawr, Pennsylvania, United States
Yakima, Washington, United States
Salina, Kansas, United States
Coon Rapids, Minnesota, United States
Renton, Washington, United States
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Carroll, Iowa, United States
Wichita, Kansas, United States
Annapolis, Maryland, United States
Ann Arbor, Michigan, United States
Minneapolis, Minnesota, United States
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Shakopee, Minnesota, United States
Willmar, Minnesota, United States
Cooperstown, New York, United States
State College, Pennsylvania, United States
Boulder, Colorado, United States
Terre Haute, Indiana, United States
Council Bluffs, Iowa, United States
Chesterfield, Missouri, United States
Asheboro, North Carolina, United States
Dayton, Ohio, United States
Effingham, Illinois, United States
Independence, Kansas, United States
Lawrence, Kansas, United States
Lee's Summit, Missouri, United States
Saint Joseph, Missouri, United States
Greenville, Ohio, United States
Mount Vernon, Ohio, United States
Bethlehem, Pennsylvania, United States
Wisconsin Rapids, Wisconsin, United States
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Doylestown, Pennsylvania, United States
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Butte, Montana, United States
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Galesburg, Illinois, United States
Cedar Rapids, Iowa, United States
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Jackson, Michigan, United States
Lansing, Michigan, United States
Warren, Michigan, United States
Brainerd, Minnesota, United States
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Lincoln, Nebraska, United States
Papillion, Nebraska, United States
Anchorage, Alaska, United States
Omaha, Nebraska, United States
Minneapolis, Minnesota, United States
Reed City, Michigan, United States
Cape Girardeau, Missouri, United States
Peru, Illinois, United States
Des Moines, Iowa, United States
Adrian, Michigan, United States
Monroe, Michigan, United States
Pontiac, Michigan, United States
Maplewood, Minnesota, United States
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Stillwater, Minnesota, United States
Great Falls, Montana, United States
Findlay, Ohio, United States
Sandusky, Ohio, United States
Toledo, Ohio, United States
Toledo, Ohio, United States
Hazleton, Pennsylvania, United States
Sayre, Pennsylvania, United States
Wilkes Barre, Pennsylvania, United States
Spartanburg, South Carolina, United States
Seneca, Pennsylvania, United States
Providence, Rhode Island, United States
Kalamazoo, Michigan, United States
West Islip, New York, United States
Scranton, Pennsylvania, United States
Bremerton, Washington, United States
Paoli, Pennsylvania, United States
Atlanta, Georgia, United States
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Los Angeles, California, United States
Redwood City, California, United States
Richmond, California, United States
Roseville, California, United States
Sacramento, California, United States
San Francisco, California, United States
San Jose, California, United States
San Leandro, California, United States
Santa Clara, California, United States
Santa Rosa, California, United States
South San Francisco, California, United States
Stockton, California, United States
Vallejo, California, United States
Walnut Creek, California, United States
Walnut Creek, California, United States
Hartford, Connecticut, United States
Seaford, Delaware, United States
Lawrenceville, Georgia, United States
'Aiea, Hawaii, United States
Honolulu, Hawaii, United States
Honolulu, Hawaii, United States
Honolulu, Hawaii, United States
Alton, Illinois, United States
Galesburg, Illinois, United States
Joliet, Illinois, United States
Pekin, Illinois, United States
Rockford, Illinois, United States
Richmond, Indiana, United States
Ames, Iowa, United States
Davenport, Iowa, United States
Davenport, Iowa, United States
Kansas City, Kansas, United States
Pittsburg, Kansas, United States
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Wichita, Kansas, United States
New Orleans, Louisiana, United States
Baltimore, Maryland, United States
Largo, Maryland, United States
Salisbury, Maryland, United States
Worcester, Massachusetts, United States
Battle Creek, Michigan, United States
Dearborn, Michigan, United States
Grand Rapids, Michigan, United States
Grand Rapids, Michigan, United States
Muskegon, Michigan, United States
Saginaw, Michigan, United States
Saint Joseph, Michigan, United States
Bemidji, Minnesota, United States
Woodbury, Minnesota, United States
Joplin, Missouri, United States
Kansas City, Missouri, United States
Kansas City, Missouri, United States
Springfield, Missouri, United States
Springfield, Missouri, United States
Billings, Montana, United States
Billings, Montana, United States
Missoula, Montana, United States
Reno, Nevada, United States
Mount Holly, New Jersey, United States
Voorhees, New Jersey, United States
Burlington, North Carolina, United States
Pinehurst, North Carolina, United States
Reidsville, North Carolina, United States
Akron, Ohio, United States
Boardman, Ohio, United States
Canton, Ohio, United States
Dayton, Ohio, United States
Franklin, Ohio, United States
Sylvania, Ohio, United States
Toledo, Ohio, United States
Troy, Ohio, United States
Warren, Ohio, United States
Wright Patterson Air Force Base, Ohio, United States
Youngstown, Ohio, United States
Portland, Oregon, United States
East Stroudsburg, Pennsylvania, United States
Ephrata, Pennsylvania, United States
West Reading, Pennsylvania, United States
Sioux Falls, South Dakota, United States
Richmond, Virginia, United States
South Hill, Virginia, United States
Tacoma, Washington, United States
Tacoma, Washington, United States
Vancouver, Washington, United States
Eau Claire, Wisconsin, United States
Fond Du Lac, Wisconsin, United States
Green Bay, Wisconsin, United States
Mequon, Wisconsin, United States
Milwaukee, Wisconsin, United States
Minocqua, Wisconsin, United States
Oconomowoc, Wisconsin, United States
Oconto Falls, Wisconsin, United States
Racine, Wisconsin, United States
Rhinelander, Wisconsin, United States
Rice Lake, Wisconsin, United States
Sheboygan, Wisconsin, United States
Stevens Point, Wisconsin, United States
Waukesha, Wisconsin, United States
Wausau, Wisconsin, United States
West Allis, Wisconsin, United States
Weston, Wisconsin, United States
Kettering, Ohio, United States
Berkeley, California, United States
Emeryville, California, United States
Mountain View, California, United States
Palo Alto, California, United States
Redding, California, United States
San Francisco, California, United States
Aurora, Colorado, United States
Colorado Springs, Colorado, United States
Denver, Colorado, United States
Lakewood, Colorado, United States
Stamford, Connecticut, United States
Jacksonville, Florida, United States
Savannah, Georgia, United States
Chicago, Illinois, United States
Cedar Rapids, Iowa, United States
Burlington, Massachusetts, United States
Concord, New Hampshire, United States
Manchester, New Hampshire, United States
Albuquerque, New Mexico, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Marietta, Ohio, United States
Newark, Ohio, United States
Springfield, Ohio, United States
Westerville, Ohio, United States
Wooster, Ohio, United States
Zanesville, Ohio, United States
York, Pennsylvania, United States
Bellingham, Washington, United States
Seattle, Washington, United States
Huntington, West Virginia, United States
Antigo, Wisconsin, United States
Wausau, Wisconsin, United States
Seattle, Washington, United States
Libertyville, Illinois, United States
Livonia, Michigan, United States
East Syracuse, New York, United States
Mansfield, Ohio, United States
Bremerton, Washington, United States
Kennewick, Washington, United States
Sedro Woolley, Washington, United States
Kailua, Hawaii, United States
Clackamas, Oregon, United States
Newberg, Oregon, United States
Oshkosh, Wisconsin, United States
Munster, Indiana, United States
Littleton, Colorado, United States
New Ulm, Minnesota, United States
Albuquerque, New Mexico, United States
Boise, Idaho, United States
Charleston, West Virginia, United States
Denver, Colorado, United States
Denver, Colorado, United States
Saint Helena, California, United States
Castro Valley, California, United States
Marysville, California, United States
Moline, Illinois, United States
White Plains, New York, United States
Hendersonville, North Carolina, United States
Independence, Ohio, United States
Norton, Virginia, United States
Tucson, Arizona, United States
Saint Joseph, Michigan, United States
Las Vegas, Nevada, United States
Elgin, Illinois, United States
Honolulu, Hawaii, United States
Louisville, Kentucky, United States
Grand Junction, Colorado, United States
Torrington, Connecticut, United States
Council Bluffs, Iowa, United States
Overland Park, Kansas, United States
Hattiesburg, Mississippi, United States
Chippewa Falls, Wisconsin, United States
Canton, Illinois, United States
Carthage, Illinois, United States
Eureka, Illinois, United States
Kewanee, Illinois, United States
Macomb, Illinois, United States
Peru, Illinois, United States
Princeton, Illinois, United States
New Orleans, Louisiana, United States
Boise, Idaho, United States
Hines, Illinois, United States
Rockford, Illinois, United States
Indianapolis, Indiana, United States
Fargo, North Dakota, United States
Lynchburg, Virginia, United States
Appleton, Wisconsin, United States
Parker, Colorado, United States
La Jolla, California, United States
Lexington, Kentucky, United States
Shreveport, Louisiana, United States
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Joplin, Missouri, United States
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Austin, Texas, United States
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Fergus Falls, Minnesota, United States
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Branson, Missouri, United States
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Erie, Pennsylvania, United States
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Pottstown, Pennsylvania, United States
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Gastonia, North Carolina, United States
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Richmond, Virginia, United States
Longview, Washington, United States
Bridgeport, West Virginia, United States
Dearborn, Michigan, United States
Jonesboro, Arkansas, United States
Anaheim, California, United States
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Lihue, Hawaii, United States
Fruitland, Idaho, United States
Meridian, Idaho, United States
Nampa, Idaho, United States
Twin Falls, Idaho, United States
West Des Moines, Iowa, United States
Overland Park, Kansas, United States
Lafayette, Louisiana, United States
Bel Air, Maryland, United States
Farmington Hills, Michigan, United States
Kansas City, Missouri, United States
Lee's Summit, Missouri, United States
Rolla, Missouri, United States
Rolla, Missouri, United States
Albuquerque, New Mexico, United States
Fargo, North Dakota, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Portsmouth, Ohio, United States
Steubenville, Ohio, United States
Martinsville, Virginia, United States
Bellevue, Washington, United States
Burien, Washington, United States
Edmonds, Washington, United States
Everett, Washington, United States
Issaquah, Washington, United States
Lacey, Washington, United States
New Richmond, Wisconsin, United States
Urbana, Illinois, United States
Randallstown, Maryland, United States
Springfield, Illinois, United States
Belpre, Ohio, United States
Columbus, Ohio, United States
Delaware, Ohio, United States
Longmont, Colorado, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Mclean, Virginia, United States
Springfield, Ohio, United States
West Columbia, South Carolina, United States
Saint Peters, Missouri, United States
Beaver, Pennsylvania, United States
Greensburg, Pennsylvania, United States
Johnstown, Pennsylvania, United States
Moon, Pennsylvania, United States
Natrona Heights, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Anchorage, Alaska, United States
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Loveland, Colorado, United States
Auburn, California, United States
Davis, California, United States
Santa Cruz, California, United States
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Newark, Delaware, United States
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Rehoboth Beach, Delaware, United States
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Meridian, Idaho, United States
Nampa, Idaho, United States
Sandpoint, Idaho, United States
Fort Wayne, Indiana, United States
Clive, Iowa, United States
West Des Moines, Iowa, United States
Garden City, Kansas, United States
Great Bend, Kansas, United States
Manhattan, Kansas, United States
Brighton, Michigan, United States
Canton, Michigan, United States
Caro, Michigan, United States
Chelsea, Michigan, United States
Clarkston, Michigan, United States
Clarkston, Michigan, United States
East China Township, Michigan, United States
Flint, Michigan, United States
Flint, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Livonia, Michigan, United States
Macomb, Michigan, United States
Macomb, Michigan, United States
Marlette, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Rochester Hills, Michigan, United States
Saginaw, Michigan, United States
Sterling Heights, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
West Branch, Michigan, United States
Ypsilanti, Michigan, United States
Minneapolis, Minnesota, United States
Anaconda, Montana, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Paramus, New Jersey, United States
Westwood, New Jersey, United States
Centerville, Ohio, United States
Dublin, Ohio, United States
Grove City, Ohio, United States
Marion, Ohio, United States
Baker City, Oregon, United States
Ontario, Oregon, United States
Lewisburg, Pennsylvania, United States
Houston, Texas, United States
Sugar Land, Texas, United States
Cody, Wyoming, United States
Sun City, Arizona, United States
Anchorage, Alaska, United States
Anchorage, Alaska, United States
Anchorage, Alaska, United States
Anchorage, Alaska, United States
Anchorage, Alaska, United States
Colorado Springs, Colorado, United States
Durango, Colorado, United States
Durango, Colorado, United States
Lakewood, Colorado, United States
Thornton, Colorado, United States
Creston, Iowa, United States
Bardstown, Kentucky, United States
Corbin, Kentucky, United States
Lexington, Kentucky, United States
Lexington, Kentucky, United States
Louisville, Kentucky, United States
Shepherdsville, Kentucky, United States
Kearney, Nebraska, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Aberdeen, Washington, United States
Enumclaw, Washington, United States
Seattle, Washington, United States
Shelton, Washington, United States
Tacoma, Washington, United States
Yelm, Washington, United States
Boulder, Colorado, United States
Denver, Colorado, United States
Englewood, Colorado, United States
Littleton, Colorado, United States
Lone Tree, Colorado, United States
Carbondale, Illinois, United States
Carterville, Illinois, United States
Centralia, Illinois, United States
Danville, Illinois, United States
Decatur, Illinois, United States
Effingham, Illinois, United States
Mattoon, Illinois, United States
New Lenox, Illinois, United States
O'fallon, Illinois, United States
Swansea, Illinois, United States
Yorkville, Illinois, United States
Michigan City, Indiana, United States
Louisville, Kentucky, United States
Brighton, Michigan, United States
Brownstown, Michigan, United States
Canton, Michigan, United States
Chelsea, Michigan, United States
Clinton Township, Michigan, United States
Novi, Michigan, United States
West Bloomfield, Michigan, United States
Ypsilanti, Michigan, United States
Maple Grove, Minnesota, United States
Wyoming, Minnesota, United States
Sainte Genevieve, Missouri, United States
Sullivan, Missouri, United States
Sunset Hills, Missouri, United States
Mebane, North Carolina, United States
Centerville, Ohio, United States
Cincinnati, Ohio, United States
Dayton, Ohio, United States
Findlay, Ohio, United States
Findlay, Ohio, United States
Franklin, Ohio, United States
Greenville, Ohio, United States
Kettering, Ohio, United States
Troy, Ohio, United States
Clackamas, Oregon, United States
Bristol, Tennessee, United States
Kingsport, Tennessee, United States
Bristol, Virginia, United States
Seattle, Washington, United States
Spokane, Washington, United States
Spokane, Washington, United States
Sturgeon Bay, Wisconsin, United States
Cheyenne, Wyoming, United States
Dublin, California, United States
Lone Tree, Colorado, United States
Glenview, Illinois, United States
Highland Park, Illinois, United States
Ames, Iowa, United States
Boone, Iowa, United States
Fort Dodge, Iowa, United States
Jefferson, Iowa, United States
Marshalltown, Iowa, United States
Gulfport, Mississippi, United States
Hattiesburg, Mississippi, United States
Lincoln, Nebraska, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Auburn, New York, United States
Syracuse, New York, United States
Pottsville, Pennsylvania, United States
Lutherville, Maryland, United States
Milford, Massachusetts, United States
Richmond, Virginia, United States
Dublin, California, United States
Sacramento, California, United States
San Rafael, California, United States
Walnut Creek, California, United States
Denver, Colorado, United States
Baton Rouge, Louisiana, United States
Baton Rouge, Louisiana, United States
Baton Rouge, Louisiana, United States
Covington, Louisiana, United States
Westminster, Maryland, United States
South Weymouth, Massachusetts, United States
Norton Shores, Michigan, United States
Novi, Michigan, United States
Monticello, Minnesota, United States
Columbus, Mississippi, United States
Grenada, Mississippi, United States
New Albany, Mississippi, United States
Oxford, Mississippi, United States
Southhaven, Mississippi, United States
Creve Coeur, Missouri, United States
Saint Louis, Missouri, United States
Carson City, Nevada, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Reno, Nevada, United States
Ridgewood, New Jersey, United States
Mansfield, Ohio, United States
Broomall, Pennsylvania, United States
Ephrata, Pennsylvania, United States
Glen Mills, Pennsylvania, United States
Lebanon, Pennsylvania, United States
Gaffney, South Carolina, United States
Greenville, South Carolina, United States
Greer, South Carolina, United States
Union, South Carolina, United States
Gig Harbor, Washington, United States
Appleton, Wisconsin, United States
Brookfield, Wisconsin, United States
Eau Claire, Wisconsin, United States
Franklin, Wisconsin, United States
Oshkosh, Wisconsin, United States
Ladysmith, Wisconsin, United States
Council Bluffs, Iowa, United States
Bronx, New York, United States
Honolulu, Hawaii, United States
Aurora, Illinois, United States
Fremont, California, United States
London, Kentucky, United States
Port Townsend, Washington, United States
Milwaukee, Wisconsin, United States
'Aiea, Hawaii, United States
Washington, District Of Columbia, United States
Elizabethtown, Kentucky, United States
Kenner, Louisiana, United States
Rockport, Maine, United States
Baltimore, Maryland, United States
Gaithersburg, Maryland, United States
Londonderry, New Hampshire, United States
Charleston, South Carolina, United States
Charleston, South Carolina, United States
Mount Pleasant, South Carolina, United States
Burke, Virginia, United States
Fishersville, Virginia, United States
Mukwonago, Wisconsin, United States
'Aiea, Hawaii, United States
Carlisle, Pennsylvania, United States
Waukesha, Wisconsin, United States
Winchester, Massachusetts, United States
Ontario, California, United States
Trumbull, Connecticut, United States
Des Moines, Iowa, United States
Westwood, Kansas, United States
South Portland, Maine, United States
Ashland, Wisconsin, United States
Gahanna, Ohio, United States
Selinsgrove, Pennsylvania, United States
Corvallis, Oregon, United States
Chambersburg, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Midlothian, Virginia, United States
Orland Park, Illinois, United States
Glen Burnie, Maryland, United States
North Kansas City, Missouri, United States
Bay Shore, New York, United States
Edgewood, Kentucky, United States
Corbin, Kentucky, United States
Phoenix, Arizona, United States
San Luis Obispo, California, United States
Santa Maria, California, United States
Boulder, Colorado, United States
Sanford, Maine, United States
Tawas City, Michigan, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Moorestown, New Jersey, United States
Rio Rancho, New Mexico, United States
Perrysburg, Ohio, United States
Brewer, Maine, United States
Royal Oak, Michigan, United States
Royal Oak, Michigan, United States
Royal Oak, Michigan, United States
Royal Oak, Michigan, United States
Sterling Heights, Michigan, United States
Troy, Michigan, United States
Troy, Michigan, United States
Warrensville Heights, Ohio, United States
Seattle, Washington, United States
Fort Worth, Texas, United States
Gilbert, Arizona, United States
Derby, Connecticut, United States
Fairfield, Connecticut, United States
Guilford, Connecticut, United States
North Haven, Connecticut, United States
Orange, Connecticut, United States
Waterbury, Connecticut, United States
Waterford, Connecticut, United States
Fort Thomas, Kentucky, United States
Paducah, Kentucky, United States
Kensington, Maryland, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Pahrump, Nevada, United States
Beavercreek, Ohio, United States
Charleston, South Carolina, United States
Martinsburg, West Virginia, United States
Stevens Point, Wisconsin, United States
Abilene, Texas, United States
York, Pennsylvania, United States
Arroyo Grande, California, United States
Greenwich, Connecticut, United States
New Haven, Connecticut, United States
West Haven, Connecticut, United States
Baton Rouge, Louisiana, United States
Springfield, Massachusetts, United States
Aitkin, Minnesota, United States
Deer River, Minnesota, United States
Hibbing, Minnesota, United States
Sandstone, Minnesota, United States
Virginia, Minnesota, United States
Saint Louis, Missouri, United States
Hazleton, Pennsylvania, United States
Bluffton, South Carolina, United States
Hilton Head Island, South Carolina, United States
Collierville, Tennessee, United States
Ashland, Wisconsin, United States
Medford, Wisconsin, United States
Colorado Springs, Colorado, United States
Long Beach, California, United States
Norfolk, Virginia, United States
Honolulu, Hawaii, United States
Ballwin, Missouri, United States
Washington, Missouri, United States
Denver, Colorado, United States
Golden, Colorado, United States
Lafayette, Colorado, United States
Thornton, Colorado, United States
Honolulu, Hawaii, United States
Mooresville, Indiana, United States
Fort Dodge, Iowa, United States
Royal Oak, Michigan, United States
Worthington, Minnesota, United States
Bellevue, Nebraska, United States
Omaha, Nebraska, United States
Redmond, Oregon, United States
Royal Oak, Michigan, United States
Mechanicsville, Virginia, United States
Wauwatosa, Wisconsin, United States
Farrell, Pennsylvania, United States
Redding, California, United States
Braselton, Georgia, United States
'Aiea, Hawaii, United States
Belfast, Maine, United States
Biddeford, Maine, United States
Sanford, Maine, United States
Detroit Lakes, Minnesota, United States
Fosston, Minnesota, United States
Park Rapids, Minnesota, United States
Jamestown, North Dakota, United States
Denver, Colorado, United States
Altoona, Pennsylvania, United States
Mechanicsburg, Pennsylvania, United States
Tampa, Florida, United States
Springfield, Ohio, United States
Medford, Oregon, United States
Fargo, North Dakota, United States
Chadds Ford, Pennsylvania, United States
Madison, Wisconsin, United States
Libertyville, Illinois, United States
Kingman, Arizona, United States
Centennial, Colorado, United States
Denver, Colorado, United States
Englewood, Colorado, United States
Fort Myers, Florida, United States
Dixon, Illinois, United States
Washington, Illinois, United States
Farmington, Missouri, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Redwood City, California, United States
San Mateo, California, United States
Santa Cruz, California, United States
Upland, California, United States
Englewood, Colorado, United States
Fort Collins, Colorado, United States
Greeley, Colorado, United States
Frankford, Delaware, United States
Tampa, Florida, United States
Lafayette, Indiana, United States
Peabody, Massachusetts, United States
Burnsville, Minnesota, United States
Lincoln, Nebraska, United States
York, Pennsylvania, United States
Richmond, Virginia, United States
Chilton, Wisconsin, United States
Bozeman, Montana, United States
Alliance, Ohio, United States
Baton Rouge, Louisiana, United States
Duluth, Georgia, United States
Snellville, Georgia, United States
Silvis, Illinois, United States
Davenport, Iowa, United States
Covington, Louisiana, United States
Slidell, Louisiana, United States
Slidell, Louisiana, United States
Norway, Maine, United States
Ocean Pines, Maryland, United States
Alma, Michigan, United States
Alpena, Michigan, United States
Gladwin, Michigan, United States
Shelby, Michigan, United States
Cambridge, Minnesota, United States
Princeton, Minnesota, United States
'Ewa Beach, Hawaii, United States
Honolulu, Hawaii, United States
Kahului, Hawaii, United States
Barrington, Illinois, United States
Crystal Lake, Illinois, United States
Crown Point, Indiana, United States
Dyer, Indiana, United States
Hobart, Indiana, United States
Hobart, Indiana, United States
Indianapolis, Indiana, United States
Munster, Indiana, United States
New Albany, Indiana, United States
Valparaiso, Indiana, United States
Kalamazoo, Michigan, United States
Thief River Falls, Minnesota, United States
Omaha, Nebraska, United States
Omaha, Nebraska, United States
East Hills, New York, United States
Oneida, New York, United States
Oswego, New York, United States
Sleepy Hollow, New York, United States
Clemmons, North Carolina, United States
Greensboro, North Carolina, United States
Statesville, North Carolina, United States
Dublin, Ohio, United States
Camp Hill, Pennsylvania, United States
Chambersburg, Pennsylvania, United States
East Norriton, Pennsylvania, United States
Greenville, Pennsylvania, United States
Indiana, Pennsylvania, United States
Monroeville, Pennsylvania, United States
Mount Pleasant, Pennsylvania, United States
N. Huntingdon, Pennsylvania, United States
New Castle, Pennsylvania, United States
Uniontown, Pennsylvania, United States
Washington, Pennsylvania, United States
West Mifflin, Pennsylvania, United States
Williamsport, Pennsylvania, United States
Baytown, Texas, United States
Houston, Texas, United States
Nassau Bay, Texas, United States
Richardson, Texas, United States
The Woodlands, Texas, United States
Midlothian, Virginia, United States
Cudahy, Wisconsin, United States
Tamuning, , Guam
Paramus, New Jersey, United States
Neenah, Wisconsin, United States
Westerly, Rhode Island, United States
Missoula, Montana, United States
Annapolis, Maryland, United States
Fargo, North Dakota, United States
Fargo, North Dakota, United States
Portsmouth, Virginia, United States
Suffolk, Virginia, United States
Greeley, Colorado, United States
'Aiea, Hawaii, United States
Alton, Illinois, United States
Springfield, Illinois, United States
Grand Island, Nebraska, United States
Asheboro, North Carolina, United States
Perrysburg, Ohio, United States
Toledo, Ohio, United States
Aurora, Colorado, United States
Shiloh, Illinois, United States
Pekin, Illinois, United States
Portland, Oregon, United States
Kansas City, Missouri, United States
Cumberland, Maryland, United States
Des Moines, Iowa, United States
Kalispell, Montana, United States
Dallas, Texas, United States
Lebanon, New Hampshire, United States
Moon, Pennsylvania, United States
West Islip, New York, United States
Wyoming, Michigan, United States
Grand Rapids, Michigan, United States
Muskegon, Michigan, United States
Troy, Ohio, United States
Nampa, Idaho, United States
Alcoa, Tennessee, United States
Pontiac, Michigan, United States
Ann Arbor, Michigan, United States
Brighton, Michigan, United States
Chelsea, Michigan, United States
Foxboro, Massachusetts, United States
Danville, Illinois, United States
Guilford, Connecticut, United States
Boone, Iowa, United States
Fort Dodge, Iowa, United States
Jefferson, Iowa, United States
Marshalltown, Iowa, United States
Munster, Indiana, United States
Ames, Iowa, United States
Canton, Michigan, United States
Rhinelander, Wisconsin, United States
Stevens Point, Wisconsin, United States
Ladysmith, Wisconsin, United States
Minocqua, Wisconsin, United States
Columbia, Missouri, United States
Asheboro, North Carolina, United States
Osage Beach, Missouri, United States
Greenville, Pennsylvania, United States
Verona, New York, United States
Verona, New York, United States
Ankeny, Iowa, United States
Sunset Hills, Missouri, United States
Marysville, Ohio, United States
Niles, Michigan, United States
Reed City, Michigan, United States
Saint Joseph, Michigan, United States
Des Moines, Iowa, United States
Clive, Iowa, United States
Woodbridge, Virginia, United States
Lincoln, Nebraska, United States
Lansing, Michigan, United States
Richmond, Virginia, United States
Grand Rapids, Michigan, United States
Loveland, Colorado, United States
Rockford, Illinois, United States
Concord, California, United States
Hays, Kansas, United States
Saint Joseph, Michigan, United States
Jefferson City, Missouri, United States
Fort Thomas, Kentucky, United States
Pontiac, Michigan, United States
Council Bluffs, Iowa, United States
Madison, Wisconsin, United States
Lynchburg, Virginia, United States
Ridgewood, New Jersey, United States
Hanover, Pennsylvania, United States
Martinsville, Virginia, United States
Silverdale, Washington, United States
Saint Johnsbury, Vermont, United States
Dayton, Ohio, United States
Grand Rapids, Michigan, United States
Royal Oak, Michigan, United States
Johnson Creek, Wisconsin, United States
Sandpoint, Idaho, United States
Baker City, Oregon, United States
Ontario, Oregon, United States
East Hills, New York, United States
Dearborn, Michigan, United States
Farmington Hills, Michigan, United States
Troy, Michigan, United States
Lexington, Kentucky, United States
Millville, Delaware, United States
Saginaw, Michigan, United States
Tawas City, Michigan, United States
Camillus, New York, United States
Lafayette, Colorado, United States
Southfield, Michigan, United States
Novi, Michigan, United States
Madison, Wisconsin, United States
Detroit, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Macomb, Michigan, United States
Warren, Michigan, United States
Johnson City, Tennessee, United States
Flint, Michigan, United States
Kalamazoo, Michigan, United States
Warren, Michigan, United States
Norton, Virginia, United States
Bristol, Virginia, United States
Kearney, Nebraska, United States
East China Township, Michigan, United States
Macomb, Michigan, United States
Warren, Michigan, United States
Harbor City, California, United States
Denver, Colorado, United States
Olathe, Kansas, United States
Grosse Pointe Woods, Michigan, United States
Rochester Hills, Michigan, United States
Mount Vernon, Illinois, United States
Ankeny, Iowa, United States
Clive, Iowa, United States
Des Moines, Iowa, United States
Des Moines, Iowa, United States
Denver, Colorado, United States
Davenport, Iowa, United States
Waukee, Iowa, United States
Rolla, Missouri, United States
Davenport, Iowa, United States
Silvis, Illinois, United States
Asheboro, North Carolina, United States
Pittsburg, Kansas, United States
Raleigh, North Carolina, United States
Littleton, Colorado, United States
Parker, Colorado, United States
Cape Girardeau, Missouri, United States
Union, South Carolina, United States
Winchester, Massachusetts, United States
Biddeford, Maine, United States
Sanford, Maine, United States
South Portland, Maine, United States
Belfast, Maine, United States
Norway, Maine, United States
Kearney, Nebraska, United States
Brighton, Massachusetts, United States
Ballwin, Missouri, United States
Saint Louis, Missouri, United States
Kalamazoo, Michigan, United States
Kalamazoo, Michigan, United States
Fort Dodge, Iowa, United States
Durango, Colorado, United States
Patients applied
Trial Officials
Jacob M Sands
Principal Investigator
Alliance for Clinical Trials in Oncology
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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