Forced Oscillometry in Infants with Bronchopulmonary Dysplasia

Launched by WINSTON MANIMTIM · Feb 12, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a method called forced oscillometry (FOT) to better understand how the lungs work in infants with a condition known as bronchopulmonary dysplasia (BPD). BPD often affects premature babies and can lead to breathing difficulties. The researchers want to see how well this technique can measure lung function in both premature infants with BPD and term infants who do not have any lung issues.

If you have a premature baby with BPD who is breathing room air or receiving a small amount of oxygen but can breathe without assistance for short periods, they might be eligible to participate in this study. Additionally, healthy infants older than 36 weeks who are less than 4 weeks old may also join. During the trial, participants will undergo non-invasive tests to check their lung function, which means there won't be any uncomfortable procedures involved. This study is currently looking for participants, and it aims to help improve the understanding and treatment of breathing problems in infants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Preterm Cohort:
• • Premature infants with BPD who are in room air based on the (per NICHD definition)
• • Premature infants with BPD who are receiving low flow O2 support and able to maintain normal spO2 in Room air for brief period ( up to 3 minutes) Term Cohort without pulmonary disease
• • Infants \>36 weeks gestational age without pulmonary disease
• • Infants \< 4 weeks of age
• Outpatient Cohort:
• • Former preterm infants \< 32 weeks at birth
• • Those with BPD based on NIH 2001 definition
• • Seen prior to 2 years of age
• Exclusion Criteria:
• • Infants with BPD requiring invasive or non-invasive positive pressure ventilation
• • Infants with BPD who have associated genetic diagnosis or major congenital anomalies.