HOT HMV 2: A Phase 4 Study

Launched by GUY'S AND ST THOMAS' NHS FOUNDATION TRUST · Feb 14, 2020

Keywords

ClinConnect Summary

Following publication of the home oxygen therapy-home mechanical ventilation (HOT-HMV) trial, the purpose of this study is to evaluate the clinical service delivery of home non-invasive ventilation (NIV) therapy in patients who have recently undergone, and recovered, from a life-threatening exacerbation of COPD.

This prospective cohort observational study is designed to evaluate the clinical implementation of the delivery of home non-invasive ventilation in COPD patients with persistent hypercapnia following an acute exacerbation of COPD to validate that the clinical benefit demonstrated b...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient suspected or with proven diagnosis of COPD
• • Admission to hospital with life-threatening exacerbation of COPD requiring acute NIV (at admission evidence of decompensated Chronic Respiratory Insufficiencies (PaCO2 \> 6kPa, pH \<7.35)
• • Arterial partial pressure of carbon dioxide (PaCO2) \> 6kPa at discharge from hospital
• • Discharge from hospital without combined home non-invasive ventilation and home oxygen therapy
• • Patient willing to consider home non-invasive ventilation in addition to home oxygen therapy
• • Patient suitable for home oxygen therapy (appropriate risk assessment)
• Exclusion Criteria:
• • Patient already established on home non-invasive ventilation and home oxygen therapy
• • Patient unable to support home non-invasive ventilation e.g. unable to apply mask, lacking social support
• • Patient on palliative care pathway
• • Patient outside of usual catchment area for Lane Fox Respiratory Service