Genetic Polymorphisms of ABCB11 and ABCB4 in Women With Intrahepatic Cholestasis of Pregnancy (ICP) and in Their First Degree Relatives
Launched by ALEXANDRA HOSPITAL, ATHENS, GREECE · Feb 20, 2020
Trial Information
Current as of June 06, 2025
Unknown status
Keywords
ClinConnect Summary
Introduction: ICP is commolnly manifested in the 2nd and especially in the 3rd trimester of pregnancy. Pathogenesis of ICP is multifactorial implicating genetic, environmental and hormonologic factors. Prevalence of ICP varies. In certain populations in latin America occurrence of ICP is up to 15% of pregnancies. In Caucasian populations incidence of ICP is approximately 1% of pregnancies. Data for the Greek population are scarce. Genes ABCB4 and ABCB11 that are encoding transport proteins in the hepatocyte are implicated in the pathogenesis of ICP.
Aim of the Study: To study the genetic p...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • pregnant women with ICP
- Exclusion Criteria:
- • women with known hepatic disease ( HBV, HCV, HIV, HEV, Autoimmune Hepatitis, Drug induced liver injury, cirrhosis)
- • women with pregnancy related liver disease (pre-eclampsia, acute fatty liver of pregnancy or HELLP syndrome)
About Alexandra Hospital, Athens, Greece
Alexandra Hospital, located in Athens, Greece, is a prominent clinical research institution dedicated to advancing medical knowledge and improving patient care through rigorous clinical trials. With a commitment to innovation and excellence, the hospital collaborates with leading healthcare professionals and researchers to conduct studies across various therapeutic areas. Its state-of-the-art facilities and adherence to the highest ethical standards ensure the safety and welfare of participants, while contributing valuable insights to the global medical community. Alexandra Hospital is recognized for its comprehensive approach to clinical research, fostering an environment of collaboration and scientific inquiry.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Athens, , Greece
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials