Skeletal Fragility in Type 1 Diabetes: Glycemic Control and Bone Strength

Launched by COLUMBIA UNIVERSITY · Feb 27, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how type 1 diabetes (T1D) affects bone health in children and teenagers. Researchers want to compare the bone strength of young people with T1D to those without the condition. By understanding these differences, the study aims to learn more about how diabetes might impact bones as kids grow.

To be eligible for this study, participants should be children or adolescents who are just about to start their growth spurt, typically between the ages of 2 to 18 years. For those with T1D, it's important that they have a confirmed diagnosis and need insulin to manage their diabetes. Participants will undergo various tests to evaluate their bone health and may need to provide some health information. This study is currently looking for participants, and it aims to help improve understanding and management of bone health in young people with type 1 diabetes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria (T1D and Controls):
• • - Children within 2 years preceding the onset of the pubertal growth spurt
• Inclusion Criteria (T1D participants):
• • - documentation of β-cell autoimmunity and need for insulin replacement
• Exclusion Criteria:
• • Estimated glomerular filtration rate (eGFR)\< 60 ml/mim
• • 25(OH)D level \< 20 ng/ml.
• • Celiac disease
• • Autoimmune thyroid disease
• • Addison's disease
• • History of pathological fractures
• • -- Disorders associated with altered skeletal structure or function
• • Bone active drugs in past year
• • Diabetes of other or unclear etiology