Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid

Launched by BOSTON CHILDREN'S HOSPITAL · Feb 28, 2020

Keywords

ClinConnect Summary

**Trial Summary: Initial Pain Management in Pediatric Pancreatitis**

This clinical trial is investigating how to manage pain in children and young adults with acute pancreatitis, a condition where the pancreas becomes inflamed and causes severe abdominal pain. The study compares two approaches: one that focuses on using non-opioid pain relief methods (like acetaminophen or ibuprofen) and the current practice at Boston Children's Hospital, which primarily uses opioids (strong pain medications like morphine) for immediate pain relief. The goal is to see how effective these different pain management strategies are and to gather information that could help design larger studies in the future.

To be eligible for this trial, participants must be under 21 years old, weigh at least 8 kg, and be diagnosed with acute pancreatitis. However, those with certain health conditions, allergies to specific pain medications, or a history of substance abuse will not be able to participate. If you or someone you know qualifies, taking part in this trial means receiving either opioid or non-opioid pain relief while monitoring how well these treatments work. This study aims to improve pain management approaches for young patients with pancreatitis, ensuring they receive the best possible care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients who present to the ED and are admitted to BCH with a diagnosis of acute pancreatitis or an acute bout of chronic pancreatitis based on INSPPIRE14 Criteria (Appendix 1)
• • 2. Age ≤21 years
• • 3. Patient weight ≥8 kg
• Exclusion Criteria:
• • 1. Allergy to morphine (and hydromorphone) or aspirin/NSAID
• • 2. History of renal or hepatic insufficiency
• • 3. History of peptic ulceration
• • 4. History of bleeding diathesis
• • 5. Pregnant females
• • 6. Patients who have a documented history of substance abuse disorder or those who use opioids chronically
• • 7. Patients admitted to the Intensive Care Unit (ICU)
• • 8. Patients who received intravenous opioid patient-controlled analgesia (PCA) in transit or during their ED admission.