Methylene Blue and Microcirculation in Septic Shock
Launched by CAIRO UNIVERSITY · Mar 3, 2020
Trial Information
Current as of July 02, 2025
Unknown status
Keywords
ClinConnect Summary
The mortality rate of patients with septic shock remains very high. Arterial hypotension, related to arteriolar vasodilation and myocardial depression are the mainstays of septic shock pathology.
At the level of the micro-circulation, there is insufficient delivery of oxygen to organs and tissues which results in organ dysfunction and potential organ necrosis.One key factor leading to vascular dysfunction is the inappropriately increased production of nitric oxide within the blood vessel endothelium. Elevated levels of nitric oxide results in the blood vessel endothelium receiving direct v...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Septic shock
- • The patient is on norepinephrine infusion
- Exclusion Criteria:
- • Elevated serum creatinine (above 1.4 mg/dL)
- • Pregnancy
About Cairo University
Cairo University, a premier institution in Egypt, is dedicated to advancing medical research and education through innovative clinical trials. With a strong emphasis on improving healthcare outcomes, the university collaborates with various stakeholders to conduct rigorous scientific studies that address critical health challenges. Leveraging its extensive resources and expert faculty, Cairo University aims to contribute valuable insights to the medical community and enhance patient care both locally and globally. Through its commitment to ethical research practices and excellence, the university plays a pivotal role in shaping the future of healthcare in the region.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cairo, , Egypt
Patients applied
Trial Officials
Ahmed Mukhtar, Professor
Principal Investigator
Professor of anesthesia
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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