Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)

Launched by SOPHIA KOUTSOGIANNAKI · Mar 3, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how a procedure called cardiopulmonary bypass (CPB) can lead to a serious condition known as acute lung injury (ALI) in young children. After heart surgery that requires CPB, some children may experience problems with their lungs, which can keep them in the intensive care unit (ICU) longer and can even be life-threatening. The researchers want to understand how this happens in order to improve care and outcomes for these patients.

To participate in the trial, children must be under 12 months old and scheduled for heart surgery that requires CPB. They also need to have a certain level of oxygen in their blood before the surgery. Unfortunately, children who don't meet these conditions, such as those needing oxygen therapy or with low oxygen levels before surgery, cannot take part. If eligible, participants will undergo regular assessments to help the researchers learn more about how CPB affects lung health. This study is currently recruiting participants, and parents or guardians will need to give their consent for their child to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Are \< 12months of age
• • Scheduled for cardiac surgical needing CPB
• • Preoperative SpO2 \> 90%
• Exclusion Criteria:
• • Lack of parental (or legal guardian's) consent
• • Preoperative SpO2 \< 90%
• • Preoperative oxygen therapy