Brain Health in Breast Cancer Survivors

Launched by JONSSON COMPREHENSIVE CANCER CENTER · Mar 4, 2020

Keywords

ClinConnect Summary

This clinical trial, titled "Brain Health in Breast Cancer Survivors," is looking at how a common treatment for hormone receptor positive breast cancer, called endocrine therapy (ET), may affect brain health and thinking skills in women who have survived breast cancer. Researchers want to understand if the effects of ET on cognition, or mental abilities, differ based on whether a woman is premenopausal or postmenopausal. They will use special brain imaging techniques to get more accurate insights into how ET influences brain function.

To be eligible for the study, women aged 35 to 65 who are fluent in English and have good vision and hearing can participate. However, those with certain health conditions, such as dementia, major psychiatric disorders, or a history of significant neurological issues, are not eligible. Participants will undergo brain scans and cognitive testing, and the study aims to provide clearer answers about the impact of ET on cognitive health in breast cancer survivors. If you’re interested, this could be a valuable opportunity to contribute to important research while learning more about your own brain health.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Age 35-65
• • Fluent in English
• • Adequate vision/hearing to complete testing
• Exclusion Criteria:
• • History of major or mild neurocognitive disorder or dementia
• • Diagnosis of major neurological condition (e.g., epilepsy, Parkinson's Disease, stroke)
• • Diagnosis of a major psychiatric disorder (e.g., bipolar disorder, schizophrenia)
• • Untreated/unstable unipolar depression or anxiety
• • Prior history of cancer or chemotherapy (for controls, any history)
• • History of a learning disorder
• • History of head injury with loss of consciousness \>20 minutes
• • History of salpingo-oophorectomy or hysterectomy
• • A cardiac pacemaker
• • Implanted electronic device
• • Claustrophobia
• • Currently pregnant
• • Orbital metal implant or other metallic foreign bodies
• • Additional exclusion criteria for controls: current use of a contraceptive agent that interferes with endogenous hormonal fluctuation (e.g., oral contraceptive pill) or precludes determination of menstrual pattern (e.g., hormonally secreting intrauterine device), or current treatment with systemic estrogen replacement therapy.