Antibiotic Prophylaxis in High-Risk Arthroplasty Patients

Launched by MAYO CLINIC · Mar 3, 2020

Keywords

ClinConnect Summary

The purpose of this research study is to investigate whether a 7-day course of an oral, prophylactic antibiotic following elective, primary total hip and knee arthroplasty effectively decreases the risk of periprosthetic joint infection or wound complications following surgery in a patient population that is high-risk for these complications. Patient with one or more of the following risk factors are considered high-risk for periprosthetic joint infection and/or wound complications: body mass index over 35kg/m\^2, diagnosis of diabetes, chronic kidney disease, active tobacco user, nasal col...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient is a candidate for elective, primary total hip arthroplasties (THA) or total knee arthroplasties (TKA).
• * Patient is considered high-risk for developing Periprosthetic joint infections (PJI) based on having at least one of the following criteria:
• • Body mass index (BMI) \> 35 kg/m\^2;
• • Diagnosis of diabetes mellitus;
• • Active tobacco smoker;
• • Chronic kidney disease;
• • Autoimmune disease;
• • Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-sensitive Staphylococcus aureus (MSSA).
• Exclusion Criteria:
• • Inability to consume oral antibiotics.
• • Allergy to antibiotic alternatives in the protocol.
• • History of clostridium difficile colitis.
• • Revision hip or knee arthroplasty procedure.
• • Non-elective surgery.
• • Hemiarthroplasty.
• • Unicompartmental knee arthroplasty.
• • Simultaneous bilateral THA or TKA.
• • Will have subsequent THA or TKA within 12 weeks of the index study procedure.
• • Pregnant.