Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated with Chemoradiation Therapy

Launched by ABRAMSON CANCER CENTER AT PENN MEDICINE · Mar 10, 2020

Keywords

ClinConnect Summary

Lung cancer is both the most common malignancy worldwide and the leading cause of cancer death in the US. While radiation therapy is highly effective for many solid tumors, thoracic radiation therapy carries a risk of cardiovascular morbidity and mortality that limits critical gains in cancer control and survival. The investigators will perform detailed cardiovascular phenotyping using biologic and imaging markers to define functional and physiologic perturbations that occur with radiation therapy. The study will provide insights into how cardiovascular risk factors and disease impact these...

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Eligibility criteria

• Inclusion Criteria:
• • At least 18 years of age
• • Histologically confirmed or clinically diagnosed non-small cell lung cancer where the plan is for definitive treatment that includes radiation
• • Able to give written informed consent
• Exclusion Criteria:
• • Pregnant or breast-feeding
• • Prior treatment with anthracyclines
• • Radiation treatment not expected to involve any heart exposure as determined by treating provider
• • ECOG performance status greater than 2
• • Vulnerable patients, including pregnant women and prisoners
• • Contraindication to rest/vasodilator stress PET/CT, including: asthma with ongoing wheezing at time of enrollment; known Mobitz Type II AV block, 3rd degree AV block, or sick sinus syndrom, without a pacemaker; systolic blood pressure less than 90mmHg; known hypersensitivity to Regadenoson and adenosine; profound sinus bradycardia (heart rate less than 40bpm).