Characterization of Vaginal, Urinary and Fecal Microbiomes in Women with Recurrent Urinary Tract Infections

Launched by HADASSAH MEDICAL ORGANIZATION · Mar 10, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how the bacteria found in the vagina, urine, and stool might affect postmenopausal women who experience frequent urinary tract infections (UTIs). The researchers want to see if differences in these bacteria could make some women more likely to get UTIs repeatedly. To do this, they will compare the bacteria profiles of women who have had multiple UTIs to those who have not had any UTIs.

To participate in this study, women need to be postmenopausal and have had at least two documented UTIs in the last six months or three in the past year. Women who have certain medical conditions, such as a neurogenic bladder or known immune system issues, or who have taken antibiotics or probiotics recently, will not be eligible. Women who have never had a UTI and meet other health criteria may serve as a comparison group. Participants can expect to provide samples for testing and contribute to important research that could help improve the understanding and treatment of recurrent urinary tract infections in women.

Gender

FEMALE

Eligibility criteria

• Patients' inclusion criteria:
• • Menopausal status
• • Two or more documented, culture-positive infections in the last six months or ≥3 infections in the last year Patients' exclusion criteria
• • Neurogenic bladder condition
• • Known immunodeficiencies
• • Usage of antibiotics or probiotics within the previous month
• • Known renal calculi or anatomic malformations
• Control subjects- Inclusion criteria:
• • Menopausal status
• • Sterile urine cultures, normal urinalysis, and negative sexually-transmitted PCR urine assay
• Control subjects- Exclusion criteria:
• • - A prior history of UTIs or other urologic abnormalities.