Cytokine and Stress Hormone Responses to Exercise-induced Hypoxemia Among Endurance-trained

Launched by GEPNER YFTACH · Mar 11, 2020

Keywords

ClinConnect Summary

Fifty highly trained endurance runners (men and women, age: 18-35 years) will be recruited for this study. The first testing session will serve as a screening tool to determine subject eligibility. Following the first testing sessions subjects will be divided into EIAH or non-EIAH groups based on SaO2 at VO2max (EIAH \< 93%, non-EIAH \> 95%; Dempsey and Wagner criteria). Subjects with intermediate SaO2 (93-95% at VO2max) values will be included in the study for correlational analyses only.

All subjects will be advised orally, and in writing, as to the nature of the experiments and will giv...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1) Physically active (minimum of 50 km running/week) and maximal oxygen consumption \> 55 and 50 ml/kg-1/min-1 for men and women, respectively.
• • 2) classified as low risk based on a medical questionnaire, body mass index and non-smoking status.
• • 3) No history of pulmonary, metabolic and/or cardiovascular disease.
• • 4) normal pulmonary function as defined by a ≥ 80% of predicted forced vital capacity (FVC), forced expired volume in one second (FEV1) and FEV1/FVC according the American Thoracic Society standards.
• Exclusion Criteria:
• • Smoking and/or any pulmonary, metabolic and/or cardiovascular disease.
• • maximal oxygen consumption lower than set criteria.